METHAMPHETAMINE ABUSE--NATURAL HISTORY,TREATMENT EFFECTS

描述：（申请人摘要） 苯丙胺和甲基苯丙胺的使用及其后果有所增加 在过去的四年里，戏剧性的。 在美国的许多地区，治疗 州和联邦资助项目的入学人数几乎是 1992年到1995年。 如果这些趋势继续下去，许多国家的地方处理系统 必须为客户的大幅增加做好准备。 然而，在这方面， 尽管目前问题日益严重，但A/M使用的悠久历史 一些领域，增加立法兴趣，并开始关注 在制定具体的治疗方案时， 就地治疗的结果或药物使用者的自然史。 在拟议的项目中，初步面试将提供广泛的基础， 关于A/M用户的信息，重点关注400名A/M依赖用户的样本 1995-96年，在洛杉矶县的治疗项目中， 这 采访将涵盖用户的历史之前，期间，和之后， 识别治疗事件。 将进行第二次面试 大约两年后，在该队列中， 入院史总计约5年。 该研究将提供 全面的数据库，包括人口统计学、家庭风险因素、 与艾滋病相关的危险行为，医疗，社会和犯罪史，终身 药物使用史、治疗利用和结局以及复发 模式. 使用自然历史方法可以构建 一段时间以来的吸毒模式以及审查其与 治疗事件、背景因素、其他社会服务利用， 以及犯罪、健康和艾滋病风险行为的模式。 方法 分析将包括描述性测量、方差分析（ANOVA）和 MANOVA，对数线性模型，回归和判别分析，生存 方法，马尔可夫模型和结构方程模型。 研究的主要重点将是A/M的差异结果 在社区环境中治疗。 更具体的问题包括： A/M使用者对住院治疗和门诊治疗的反应不同; 复发率与性别、年龄、种族、 管理或其他客户特征;复发/恢复 在连续治疗事件中的模式相似;降低的程度是什么 在治疗期间的犯罪行为，并保持出院后; 有没有一个多元模型可以描述 吸毒者特征与其吸毒之间的相互关系， 治疗职业;什么是治疗的平均成本每客户日和 这些与客户感知利益相比如何？ 结果将提供 A/M使用的社区方案中的当前治疗信息 及其自然历史作为研究预测因子的基础， 随着时间的推移，其使用和治疗结果的后果， 制定、实施和修改预防和治疗措施， A/M用户。

DESCRIPTION: (Applicant's Abstract) Amphetamine and methamphetamine (A/M) use and consequences have increased dramatically in the past four years. In many regions of the U.S., treatment admissions to state and federally funded programs have almost tripled from 1992 to 1995. If these trends continue, the local treatment systems in many areas must be prepared for substantial increases in clients. However, despite the currently increasing problem, the long history of A/M use in some areas, increasing legislative interest, and beginning interest in developing specific treatment protocols, little information exists on the outcomes of in-place treatment or the natural history of users of the drug. In the proposed project, an initial interview will provide a broad base of information on A/M users, focusing on a sample of 400 A/M dependent users admired to treatment programs in Los Angeles County in 1995-96. This interview will cover the user's history prior to, during, and after the identifying treatment episode. A second interview will be conducted approximately two years later on this cohort, extending the post treatment admission history to a total of about 5 years. The study will provide a comprehensive database including demographics, family risk factors, AlDS-related risk behaviors, medical, social, and criminal history, lifetime history of drug use, treatment utilization and outcomes, and relapse patterns. The natural history methodology to be used allows construction of drug use patterns over time and examination of their relationship to treatment episode(s), background factors, other social services utilization, and patterns of criminal, health, and HIV risk behaviors. Methods of analysis will include descriptive measures, analysis of variance (ANOVA) and MANOVA, loglinear modeling, regression and discriminant analysis, survival methods, Markov models, and structural equation modeling. The primary focus of the research will be differential outcomes of A/M treatment in the community setting. More specific questions include: do A/M users respond differentially to residential versus outpatient treatment; are relapse rates related to gender, age, ethnicity, route of administration, or other client characteristics; are relapse/recovery patterns similar across successive treatment episodes; what is the decrease in criminal behavior during treatment and is it maintained after discharge; is there a multivariate model which can describe the complex interrelationships among user characteristics and their drug use and treatment careers; what are average costs of treatment per client day and how do these compare to client perceived benefits. Results will provide information on the current treatment in community-based programs for A/M use and its natural history as a basis for studying the predictors and consequences of its use and treatment outcomes over time, and for developing, implementing, and modifying prevention and treatment efforts for A/M users.