ALCOHOL IN RISK BEHAVIORS AND NEUROBEHAVIORAL STATUS

描述（改编自摘要）：初步结果，从这个 研究小组认为，与预期相反，神经认知 感染HIV-1的非洲裔美国人的缺陷与以下因素有关： 酒精消费，但不是可卡因的使用。在本申请中， 首席研究员建议对这些最初的 调查结果与一系列重点次要分析的非常丰富的 NIDA资助的非裔美国人健康项目收集的数据集 （AAHP）。这项研究旨在检查神经行为的影响， 艾滋病毒/艾滋病和药物使用的社区样本中的艾滋病毒阳性和 艾滋病毒阴性的非洲裔美国人，可以说是最大的社区样本 高风险的非洲裔美国人谁已被评估与 全面的神经生物学、精神病学和心理社会学测量。 本申请中提出了两项平行研究。在研究#1中， 研究人员将研究酒精对高风险性行为的影响。 行为，无论是独立的，还是因非法药物使用而改变的， 在190名艾滋病毒阳性者和312名艾滋病毒感染者的样本中， 艾滋病毒阴性男性。在研究#2中，他们将研究 酒精对神经认知功能和神经认知功能的影响 502人的完整样本。研究人员还将研究 酒精对神经生理状态和功能的影响， 118例HIV阳性分层样本的局部血流量（rCBF） 和HIV阴性的男性使用最先进的神经成像技术 (MRI、MRS、SPECT）。在这些分析中，研究人员将 一个独特的数据集的优势，从而使用相对成本- 提高我们对酒精作用的认识的有效方法 艾滋病的发病率。

DESCRIPTION (adapted from the Abstract): Preliminary results from this research team suggest that contrary to expectations, neurocognitive deficits among African American men infected with HIV-1 are related to alcohol consumption, but not to the use of cocaine. In this application, the Principal Investigator proposes to follow-up on those initial findings with a series of focused secondary analyses on the very rich dataset collected in the NIDA-funded African American Health Project (AAHP). The study is designed to examine the neurobehavioral effects of HIV/AIDS and substance use in a community sample of HIV-positive and HIV-negative African American men, arguably the largest community sample of high-risk African American who have been assessed with a comprehensive neurobiological, psychiatric, and psychosocial measures. Two parallel studies are proposed in this application. In Study #1, the researchers will examine the contribution of alcohol to high risk sexual behaviors, both independently and as modified by illicit drug use and other psychosocial co-factors in a sample of 190 HIV-positive and 312 HIV-negative men. In Study #2, they will examine the contribution of alcohol to neurocognitive functioning and neurcognitive caseness in the full sample of 502 men. The researchers will examine, also, the role of alcohol in neurophysiologic status and functioning as indexed by regional blood flow (rCBF) in a stratified sample of 118 HIV-positive and HIV-negative men using state-of-the-art neuroimaging techniques (MRI, MRS, SPECT). In these analyses, the researchers will take advantage of a unique dataset using, thereby, a relatively cost- effective means to enhance our understanding of the role alcohol plays in HIV disease in this understudied population.