ONTOGENY OF METABOLIC CONTROLS OF INGESTIVE BEHAVIOR

说明： 从哺乳到成人摄取的转变是所有人面临的挑战 年轻的哺乳动物。在老鼠身上，这种转变是在出生后几周内完成的， 了解幼鼠正常发育的机制 完全依靠大坝进行完全独立的取水调节 可能为干预未能实现 哺乳动物一般从哺乳到断奶的过渡。在幼鼠的早期阶段 生命，调节摄取的生理信号似乎很少， 但在断奶之前，幼崽开始调节它们的摄入量，以应对 与能量代谢变化有关的信号。这里面的实验 关于大鼠摄食调节发展的建议性试题 幼崽使用这种紧急的新陈代谢反应。第一，政府的角色 使用以下方法测试特定代谢燃料(脂肪)利用率的变化 几种已知可抑制脂肪酸氧化的药理物质 几个不同的生化步骤。这些毒剂的行为影响 与它们的生化效应进行比较，以测试利用的变化 脂肪的含量会影响幼鼠的摄入量。第二，因为生理信号 可以在许多行为层面上影响摄取，摄取 代谢信号对其产生影响的行为成分 对开发进行检查以测试 能量的利用转化为摄食行为的改变。 此外，如果与能源利用的变化有关的信号 通常调节摄取，然后由代谢阻滞剂诱导进食 应类似于通过能量限制(即食物)诱导的喂养 剥夺)。因此，类似的吸收前后的生理信号 应抑制食物剥夺和药物刺激的摄入量 新陈代谢受阻。这一假设是通过检验 抑制代谢阻滞剂刺激摄取的生理信号。 最后，翻译生理变化的神经机制 与能量利用有关的摄食行为的增加是 测试过。

DESCRIPTION: The transition from suckling to adult ingestion is a challenge facing all young mammals. In rats, this transition is made within weeks of birth and understanding the mechanisms by which rat pups normally develop from complete dependence on the dam to completely independent intake regulation may provide valuable insight for intervention in failures to accomplish the suckling to weaning transition in mammals in general. Early in a rat pup's life, the physiological signals which modulate ingestion appear to be few, but prior to weaning pups begin to modulate their intake in response to a signal related to changes in energy metabolism. The experiments in this proposal test questions about the development of intake regulation in rat pups using this emergent metabolic responsiveness. First, the role of changes in utilization of a specific metabolic fuel (fat) is tested using several pharmacological agents known to inhibit oxidation of fatty acids at several different biochemical steps. The behavioral effects of these agents are compared to their biochemical effects to test changes in the utilization of fats affect intake in young rats. Second, because physiological signals can affect ingestion at a number of behavioral levels, the ingestive behavioral components on which metabolic signals exert their effects during development is examined to test the mechanisms by which changes in the utilization of energy are translated into changes in ingestive behavior. Further, if a signal related to changes in the utilization of energy normally modulates ingestion, then feeding induced by metabolic blockers should be similar to feeding induced by energy restriction (i.e. food deprivation). Thus, similar pre- and post-absorptive physiological signals should suppress intake stimulated by food deprivation and pharmacological blockade of metabolism. This hypothesis is tested by examining the physiological signals suppressing intake stimulated by metabolic blockers. Finally, the neural mechanisms involved in translating physiological changes related to energy utilization into increases in ingestive behavior are tested.