HORIZONS IN VASCULAR BIOLOGY AND THERAPEUTICS

血管生成、血管基因转移、心血管疾病、肿瘤生物学和发育生物学等领域的最新进展强调了血管在正常和病理过程中的关键作用。调节血管细胞组装、重塑和退化的分子机器的定义有望为实体肿瘤、组织缺血的治疗提供信息，并最终使针对肾小球疾病关键疾病部位的特定治疗成为可能。作为通过血管间室进入的第一条途径，内皮是一个高度专业化的界面，可以通过血管床特异性药物、重组分子、病毒载体和旨在改变病理过程和后果的治疗剂进行靶向治疗。在发育生物学、血管形成的组织模型、分子靶标识别和血管基因转移之间的接口方面的最新进展为发现、验证和应用新的治疗方法提供了一个平台。会议的总体目标是让该领域的杰出领导者接触到有前途的年轻研究人员和受训人员，评估该领域的最新进展，并预测可能对应用于肾脏、肾脏疾病和困扰肾脏患者的终末期疾病治疗的研究工作产生有利影响的未来方向。为了促进在这一迅速增长的领域中招募、支持和发展新的研究人员的努力，会议将向根据提交给会议的摘要而被认为合适的年轻研究人员和受训人员提供旅费补助金。将特别考虑妇女、种族/少数民族个人、残疾人和其他任职人数不足的人。他将举行一个海报会议，获奖者在会上展示他们的工作，供该领域的领导人审查和讨论。大会策划委员会将选出获奖者，申请机构将负责管理旅行补助金的发放。会议将在互联网上的主要科学期刊(包括一般兴趣和肾脏社区)上进行宣传，并将通知邮寄给发起组织美国肾脏学会的成员。

Recent progress in the fields of angiogenesis, vascular gene transfer, cardiovascular diseases, cancer biology, and developmental biology emphasizes the critical role the vasculature plays in normal and pathological processes. Definition of the molecular machines that mediate vascular cell assembly, remodeling, and regression promises to inform therapies for solid tumors, tissue ischemia, and ultimately to empower targeting of specific therapies to critical sites of disease in glomerulopathies. As the first avenue of access through the vascular compartment, the endothelium is a highly specialized interface accessible to targeting with vascular bed specific drugs, recombinant molecules, viral vectors and therapeutic agents designed to alter pathological processes and consequences. Recent progress at the interface between developmental biology, tissue models for vascularization, molecular target identification and vascular gene transfer offer a platform of discovery, validation and application to define new therapies. The overall goal of the conference is to bring outstanding leaders in the area into contact with promising young investigators and trainees, to evaluate the recent progress in the field and to project future directions that may impact favorably on research efforts applied to the kidney, kidney diseases and treatment of end stage conditions that afflict renal patients. To facilitate these efforts to recruit, support and develop new researchers in this rapidly growing field, the conference will offer travel grants to young investigators and trainees who are judged appropriate based on their submission of abstracts for the conference. Special consideration will be given to women, racial/ethnic minority individuals, those with disabilities, and others underrepresented. A poster session will he held in which awardees present their work for review and discussion with the leaders in this field. The planning committee for the conference will select awardees, and the applicant organization will administer award of the travel grants. The conference will be publicized in major scientific journals (both general interest and renal community focused), on the internet, and announcements will be mailed to members of the American Society of Nephrology, the sponsoring organization.