Acid-activated Cl- channels in kidney function and protection (A08 (B02))

酸激活的 Cl 通道对肾功能和保护的作用 (A08 (B02))

• 批准号: 516848547
• 金额: --
• 依托单位: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516848547?language=en
• 关键词: Acid; activated; Cl; channels; kidney

We will extend our studies on the pathophysiological roles of renal chloride channels to the acid-activated anion channel ASOR which we have recently identified to be formed by TMEM206 proteins. ASOR plays a role in acidotoxicity and stroke, as well as in macropinocytosis of macrophages and other endocytic processes. It is highly expressed in apical endosomes of the proximal tubule. Using ASOR KO mice we will investigate its potential role in renal IRI and will examine its role in endocytosis in the proximal tubule.

我们将扩大我们的研究肾氯离子通道的病理生理作用的酸激活的阴离子通道ASOR，我们最近确定由TMEM206蛋白形成。ASOR在酸毒性和中风中起作用，以及在巨噬细胞的巨胞饮和其他内吞过程中起作用。它在近端小管的顶端内体中高度表达。使用ASOR KO小鼠，我们将研究其在肾IRI中的潜在作用，并将检查其在近端小管内吞作用中的作用。