Acid-activated Cl- channels in kidney function and protection (A08 (B02))

酸激活的 Cl 通道对肾功能和保护的作用 (A08 (B02))

• 批准号: 516848547
• 金额: --
• 依托单位: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516848547?language=en
• 关键词: Acid; activated; Cl; channels; kidney

We will extend our studies on the pathophysiological roles of renal chloride channels to the acid-activated anion channel ASOR which we have recently identified to be formed by TMEM206 proteins. ASOR plays a role in acidotoxicity and stroke, as well as in macropinocytosis of macrophages and other endocytic processes. It is highly expressed in apical endosomes of the proximal tubule. Using ASOR KO mice we will investigate its potential role in renal IRI and will examine its role in endocytosis in the proximal tubule.

我们将把我们对肾脏氯通道的病理生理作用的研究扩展到酸激活的阴离子通道ASOR，我们最近发现它是由TMEM206蛋白形成的。ASOR在酸中毒和中风以及巨噬细胞的巨噬细胞吞噬和其他内吞过程中发挥作用。它在近端小管的顶端内吞体内高表达。利用ASOR KO小鼠，我们将研究其在肾脏IRI中的潜在作用，并将研究其在近端小管内吞作用中的作用。