RECEPTORS FOR ABUSED DRUGS--DEVELOPMENT AND PLASTICITY

这个应用程序请求支持一个名为“受体”的研讨会 滥用药物：发展和可塑性“，将成为该方案的一部分 在神经行为畸形学学会(NBTS)年会上。 会议将在Keystone的Keystone度假村举行， 科罗拉多州，1999年7月1日至7月4日。建议的目的是 研讨会的目的是介绍关于以下方面的知识现状 几种重要滥用药物受体的正常个体发育 急性或慢性药物暴露是如何改变这些受体的 发展。当孕妇摄入滥用药物时，可能会 对胎儿神经行为发育的不利影响 机制，包括与分子靶的直接相互作用(即， 受体)存在于胎儿大脑中。因此，至关重要的是， 研究人员研究人类或动物的产前药物效应 理解受体正常定位和时间过程的模型 发育过程中的表达以及受体的变化 出现在下面的表达式(及其功能后果) 发育期药物暴露。拟议的研讨会将把 五位领先的研究人员，每人将涵盖一种受体 选定要讨论的课程。演讲者及其主题将是 杜克大学的西奥多·斯洛特金博士将讨论尼古丁 受体，加州大学欧文分校的弗朗西斯·莱斯利博士，他 将讨论阿片受体，美国国立卫生研究院Eva Mezey博士 神经疾病和中风，谁将讨论大麻素 接受者，阿尔伯特·爱因斯坦医学院的Ratna Sircar博士，谁 将讨论苯环利定(PCP)受体，杰罗尔德·迈耶博士， 马萨诸塞大学，谁将讨论单胺转运体 (可卡因和安非他明的“受体”)。每位演讲者都将 讨论1)HIS/HER的结构、功能和定位 受体(S)，2)正常受体个体发育(出生前和/或出生后)，以及 3)发育过程中受体的可塑性和功能(即， 行为或生理)这种可塑性的后果。酒精 不会包括在这次研讨会上，部分原因是有一个 最近在NBTS举行的酒精研讨会，也是因为种类繁多 离子通道和其他被认为是分子的部分 酒精在大脑中的作用靶点。为了更广泛的目的 分发专题讨论会的介绍，总结 所有演讲者共同撰写的会议记录将被公布 神经毒理学和畸形学。

This application requests support for a Symposium entitled "Receptors for Abused Drugs: Development and Plasticity", to be part of the program at the Annual Meeting of the Neurobehavioral Teratology Society (NBTS). The meeting will take place at the Keystone Resort in Keystone, Colorado, from July 1 to July 4, 1999. The purpose of the proposed Symposium is to present the current state of knowledge concerning the normal ontogeny of receptors for several important drugs of abuse and how these receptors are altered by acute or chronic drug exposure during development. When ingested by pregnant women, abused drugs may adversely affect fetal neurobehavioral development by several mechanisms, including direct interaction with molecular targets (i.e., receptors) in the fetal brain. Thus, it is critically important for investigators studying prenatal drug effects in humans or in animal models to understand the normal localization and time course of receptor expression during development, as well as alterations in receptor expression (and their functional consequences) that occur following developmental drug exposure. The proposed Symposium will bring together five leading researchers, each of whom will cover one of receptor classes chosen for discussion. The speakers and their topics will be Dr. Theodore Slotkin, Duke University, who will discuss nicotine receptors, Dr. Frances Leslie, University of California at Irvine, who will discuss opiate receptors, Dr. Eva Mezey, National Institute on Neurological Diseases and Stroke, who will discuss cannabinoid receptors, Dr. Ratna Sircar, Albert Einstein College of Medicine, who will discuss phencyclidine (PCP) receptors, and Dr. Jerrold Meyer, University of Massachusetts, who will discuss monoamine transporters (the "receptors" for cocaine and amphetamine). Each speaker will discuss 1) the structure, function, and localization of his/her receptor(s), 2) normal receptor ontogeny (pre- and/or postnatal), and 3) receptor plasticity during development and the functional (i.e., behavioral or physiological) consequences of such plasticity. Alcohol will not be included in this Symposium, partly because there was a recent alcohol Symposium at NBTS and also because of the wide diversity of ion channels and other moieties thought to serve as the molecular targets of alcohol action in the brain. For the purpose of wider dissemination of the Symposium presentations, a summary of the proceedings jointly authored by all of the speakers will be published in Neurotoxicology and Teratology.