ASSESSMENT OF COGNITIVE FUNCTION AND RELATIONSHIP TO STRESS REACTIVITY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously shown that rhesus monkeys with SIB have a blunted stress response (low cortisol) in comparison to controls. Other studies have found that administration of cortisol interferes with performance on cognitive tasks. We tested the hypothesis that low stress reactivity would facilitate performance. Male rhesus monkeys (10 SIB, 8 Control) were exposed to a box transfer task involving visible and invisible transfers. An experimenter concealed a treat in one of three boxes. She then moved that box next to another one and transferred the treat either in sight of or out of view of the monkey; on some trials she made no transfer. The experimenter then revealed the empty box and allowed the monkey to search for the treat.