ASSESSMENT OF COGNITIVE FUNCTION AND RELATIONSHIP TO STRESS REACTIVITY

认知功能及其与应激反应关系的评估

• 批准号: 7562079
• 负责人: JERROLD S MEYER
• 金额: $ 0.53万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562079
• 关键词: Boxing; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hydrocortisone; Institution; Macaca mulatta; Monkeys; Performance; Research; Research Personnel; Resources; Source; Stress; Testing; United States National Institutes of Health; Vision; biological adaptation to stress; cognitive function; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously shown that rhesus monkeys with SIB have a blunted stress response (low cortisol) in comparison to controls. Other studies have found that administration of cortisol interferes with performance on cognitive tasks. We tested the hypothesis that low stress reactivity would facilitate performance. Male rhesus monkeys (10 SIB, 8 Control) were exposed to a box transfer task involving visible and invisible transfers. An experimenter concealed a treat in one of three boxes. She then moved that box next to another one and transferred the treat either in sight of or out of view of the monkey; on some trials she made no transfer. The experimenter then revealed the empty box and allowed the monkey to search for the treat.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们以前已经表明，与对照组相比，患有SIB的恒河猴的应激反应迟钝（皮质醇低）。其他研究发现，皮质醇的管理会干扰认知任务的表现。我们检验了低压力反应性有助于提高绩效的假设。将雄性恒河猴（10只SIB，8只对照）暴露于包括可见和不可见转移的盒子转移任务。一个实验者在三个盒子中的一个里藏了一个零食。然后，她把那个盒子移到另一个盒子旁边，把食物转移到猴子的视线内或视线外;在一些试验中，她没有转移。然后，实验者把空盒子拿出来，让猴子去找零食。