Stress, Development, and Psychopathology

描述（由申请人提供）：本申请申请支持一个题为“压力、发展和精神病理学”的研讨会，作为神经行为畸形学会年会上项目的一部分。会议将于2002年6月23日至26日在亚利桑那州斯科茨代尔的费尔蒙特公主度假村举行。许多精神病患者，特别是那些患有焦虑和情绪障碍的患者，表现出神经内分泌功能失调。特别感兴趣的是在基础和/或应激条件下下丘脑-垂体-肾上腺皮质系统的异常。此外，许多研究指出，遗传学和早期经历在为后来出现的精神病理症状和神经内分泌功能障碍“奠定基础”方面都起着关键作用。鉴于最近在这一领域令人兴奋的发现，本次研讨会将汇集五位领先的研究人员，他们正在使用各种不同的方法来研究人类和相关动物模型中异常行为发展中环境，遗传和激素因素之间的相互作用。两位演讲者，埃默里大学医学院的Paul Plotsky博士和威斯康辛大学的Mary Schneider博士，将分别报告早期应激暴露在大鼠和猴子身上的行为、神经化学和神经内分泌方面的后果。西奈山医学院的Rachel Yehuda博士和马萨诸塞大学的Jerrold Meyer博士将讨论行为病理学（Yehuda的人类创伤后应激障碍和Meyer的猴子自残行为）的神经内分泌和神经化学相关性，以及早期创伤在这种病理学发展中的作用。最后，国家儿童健康与人类发展研究所的Stephen Suomi博士将介绍猴子不同“性情”（包括冲动性和攻击性）的复杂遗传、生理和行为决定因素的研究。本次研讨会上提出的灵长类动物、啮齿动物和人类研究的独特结合，都是从不同的角度研究相同的生理系统，预计将为压力（特别是生命早期）在精神病理学中作为因果因素和结果因素的作用提供新的视角。研讨会的会议记录将作为一篇文章发表，由所有演讲者共同撰写，刊登在神经行为畸形学会主办的《神经毒理学和畸形学》杂志上。

DESCRIPTION (provided by applicant): This application requests support for a Symposium entitled "Stress, Development, and Psychopathology", to be part of the program at the Annual Meeting of the Neurobehavioral Teratology Society. The meeting will take place at the Fairmont Princess Resort in Scottsdale, Arizona, from June 23rd to June 26th, 2002. Many psychiatric patients, especially those suffering from anxiety and mood disorders, show a dysregulation of neuroendocrine function. Of particular interest are abnormalities of the hypothalamic- pituitary-adrenocortical system under basal and/or stressful conditions. Moreover, many studies point to a critical role for both genetics and early experience in "setting the stage" for the later emergence of psychopathological symptoms as well as neuroendocrine dysfunction. In light of the recent exciting findings in this area, the proposed Symposium will bring together five leading researchers who are using a variety of different approaches to investigate the interactions between environmental, genetic, and hormonal factors in the development of abnormal behaviors in humans and in relevant animal models. Two of the speakers, Dr. Paul Plotsky, Emory University School of Medicine, and Dr. Mary Schneider, University of Wisconsin, will report on the behavioral, neurochemical, and neuroendocrine consequences of early stress exposure in rats and monkeys respectively. Dr. Rachel Yehuda, Mount Sinai School of Medicine, and Dr. Jerrold Meyer, University of Massachusetts, will discuss the neuroendocrine and neurochemical correlates of behavior pathology (post-traumatic stress disorder in humans for Yehuda, and self-injurious behavior in monkeys for Meyer) and the role of early trauma in the development of such pathology. Finally, Dr. Stephen Suomi, National Institute of Child Health and Human Development, will present research on the complex genetic, physiological, and behavioral determinants of differing "temperaments" (including impulsivity and aggressiveness) in monkeys. It is expected that the unique combination of primate, rodent, and human studies presented at this Symposium, all investigating the same physiological systems but from different perspectives, will shed new light on the role of stress (particularly early in life) as both a causative and resultant factor in psychopathology. The proceedings of the Symposium will be published as a single article, jointly authored by all speakers, in Neurotoxicology and Teratology, a journal sponsored by the Neurobehavioral Teratology Society.