Stress, Development, and Psychopathology

描述(由申请者提供)：本申请请求支持一个名为“压力、发育和精神病理学”的研讨会，作为神经行为畸形学学会年会项目的一部分。会议将于2002年6月23日至26日在亚利桑那州斯科茨代尔的费尔蒙公主度假村举行。许多精神病患者，特别是那些患有焦虑和情绪障碍的患者，表现出神经内分泌功能的失调。特别令人感兴趣的是在基础和/或应激条件下下丘脑-垂体-肾上腺皮质系统的异常。此外，许多研究指出，遗传学和早期经验在为后来出现的精神病理症状和神经内分泌功能障碍“铺垫舞台”方面发挥了关键作用。鉴于最近在这一领域的令人兴奋的发现，拟议的研讨会将汇集五位领先的研究人员，他们正在使用各种不同的方法来研究环境、遗传和激素因素在人类和相关动物模型异常行为发展中的相互作用。其中两位演讲者，埃默里大学医学院的保罗·普洛茨基博士和威斯康星大学的玛丽·施奈德博士将分别报告早期应激暴露对大鼠和猴子的行为、神经化学和神经内分泌影响。西奈山医学院的雷切尔·耶胡达博士和马萨诸塞大学的杰罗尔德·迈耶博士将讨论行为病理学(耶胡达的人类创伤后应激障碍，迈耶的猴子的自伤行为)的神经内分泌和神经化学相关性，以及早期创伤在此类病理发展中的作用。最后，国家儿童健康和人类发展研究所的Stephen Suomi博士将介绍对猴子不同“气质”(包括冲动和攻击性)的复杂遗传、生理和行为决定因素的研究。预计本次研讨会上提出的灵长类、啮齿动物和人类研究的独特组合，都研究相同的生理系统，但从不同的角度，将为应激(特别是在生命早期)作为精神病理学的因果因素和结果因素的作用提供新的线索。研讨会的会议记录将作为一篇由所有演讲者共同撰写的文章发表在神经行为畸形学学会赞助的期刊《神经毒理学和畸形学》上。

DESCRIPTION (provided by applicant): This application requests support for a Symposium entitled "Stress, Development, and Psychopathology", to be part of the program at the Annual Meeting of the Neurobehavioral Teratology Society. The meeting will take place at the Fairmont Princess Resort in Scottsdale, Arizona, from June 23rd to June 26th, 2002. Many psychiatric patients, especially those suffering from anxiety and mood disorders, show a dysregulation of neuroendocrine function. Of particular interest are abnormalities of the hypothalamic- pituitary-adrenocortical system under basal and/or stressful conditions. Moreover, many studies point to a critical role for both genetics and early experience in "setting the stage" for the later emergence of psychopathological symptoms as well as neuroendocrine dysfunction. In light of the recent exciting findings in this area, the proposed Symposium will bring together five leading researchers who are using a variety of different approaches to investigate the interactions between environmental, genetic, and hormonal factors in the development of abnormal behaviors in humans and in relevant animal models. Two of the speakers, Dr. Paul Plotsky, Emory University School of Medicine, and Dr. Mary Schneider, University of Wisconsin, will report on the behavioral, neurochemical, and neuroendocrine consequences of early stress exposure in rats and monkeys respectively. Dr. Rachel Yehuda, Mount Sinai School of Medicine, and Dr. Jerrold Meyer, University of Massachusetts, will discuss the neuroendocrine and neurochemical correlates of behavior pathology (post-traumatic stress disorder in humans for Yehuda, and self-injurious behavior in monkeys for Meyer) and the role of early trauma in the development of such pathology. Finally, Dr. Stephen Suomi, National Institute of Child Health and Human Development, will present research on the complex genetic, physiological, and behavioral determinants of differing "temperaments" (including impulsivity and aggressiveness) in monkeys. It is expected that the unique combination of primate, rodent, and human studies presented at this Symposium, all investigating the same physiological systems but from different perspectives, will shed new light on the role of stress (particularly early in life) as both a causative and resultant factor in psychopathology. The proceedings of the Symposium will be published as a single article, jointly authored by all speakers, in Neurotoxicology and Teratology, a journal sponsored by the Neurobehavioral Teratology Society.