CONFERENCE ON THE CHEMISTRY AND BIOLOGY OF PEROXYNITRITE

这是第二次国际会议，第一次会议于1997年5月在瑞士的阿斯科纳举行，吸引了来自世界各地的70名科学家。 1997年会议取得成功的一个标志是发言质量极高，讨论时间长，范围广，尤其是晚上的讨论生动活泼。 在这些讨论中，我生动地回忆起迄今为止，关于过氧亚硝酸盐的争议性问题进行了批判性的讨论和评估。 第一次会议取得了巨大成功，所有与会者都强烈希望参加另一次会议，因此决定召开第二次会议。 该会议由一氧化氮协会主办（见信件）。我们预计第二次会议将汇集大约100名科学家;化学家、生物化学家、生物学家、医生、神经科学家和分子生物学家。 会议形式将与第一次会议和戈登会议类似，上午口头介绍，晚上进行小组讨论。 目的是交流信息，并就过氧亚硝酸盐的化学、生物学和医学应用进行讨论。 过氧亚硝酸盐是由一氧化氮和超氧化物反应形成的分子。过氧亚硝酸盐的许多化学和生物学功能已经被描述，但几乎每月都有新的功能或在人类病理生理学中可能的作用的报道。多年来，参与过亚硝酸盐调查的实验室数量不断增加。 以过氧亚硝酸盐为关键词在生物医学数据库中进行快速搜索，在过去八年中产生了1,000多篇文章。 然而，大多数同行评审文章（469篇）是在阿斯科纳会议后的最后两年发表的。此外，美国国立卫生研究院目前资助了第一次会议的一些与会者从事过氧亚硝酸盐的工作。 使用NIH搜索引擎，我们发现了目前由NIH资助的86个项目，以研究过氧亚硝酸盐在神经退行性疾病、呼吸窘迫、心血管疾病、癌症和许多其他疾病的致病机制中的作用。此外，该领域最重要的进展是最近的证据表明过氧亚硝酸盐介导的蛋白质硝化参与衰老神经退行性疾病的发病机制。

This is a second international conference, the first conference was held in May of 1997 in Ascona, Switzerland and attracted 70 scientists from all over the world. An indication of the success of the 1997 conference was exceptional quality of presentations, the length and extent of discussions and most of all the lively and animated evening discussions. During these discussions, which I vividly recall to date, controversial issues regarding peroxynitrite were critically discussed and evaluated. The resounding success of the first meeting and the overwhelming desire of all the participants to attend another conference resulted in the decision to put together a second meeting. The meeting is sponsored by the Nitric Oxide Society (see letters). We anticipate that the second meeting will bring together approximately 100 scientists; chemists, biochemists, biologists, physicians, neuroscientists and molecular biologists. The format will be similar to the first meeting and of Gordon conferences, with morning oral presentations followed by group discussions in the evening. The objectives will be to exchange information and engage in discussions regarding the chemistry, biology and medical applications of peroxynitrite. Peroxynitrite is the molecule formed by the reaction of nitric oxide and superoxide. A number of the chemical and biological functions of peroxynitrite have been described but almost monthly a new function or a possible role in human pathophysiology is reported. The number of laboratories contributing to investigations regarding peroxynitrite has grown over the years. A quick search in biomedical databases using peroxynitrite as the key word produced over 1,000 articles for the past eight years. However, the majority of the peer-reviewed articles (469) were published during the last two years following the Ascona meeting. Moreover, NIH currently funds a number of participants of the first meeting to work on peroxynitrite. Using the NIH search engine we found 86 projects that are currently funded by NIH to investigate the role of peroxynitrite in the pathogenic mechanism of neurodegenerative diseases, respiratory distress, cardiovascular disorders, cancer and a number of other disorders. Moreover, the most important advancements in this field are the recent evidence for the participation of peroxynitrite-mediated nitration of proteins in the pathogenesis of neurodegenerative diseases of aging.