VOLUMETRIC ANALYSIS OF THE AORTA AND ITS BRANCHES

现代螺旋CT技术结合快速静脉输液 对于碘化造影剂，允许创建体积 血管造影。到目前为止，容积血管造影术已经可视化。 定性地使用各种三维渲染技术，但是 对血管形态的系统、定量分析还没有 已经进行过了。 我们的目标是开发和验证一种容量分析方法 能够量化血管横截面积、路径 长度、曲率和树枝角度，以及壁画 斑块/血栓特征，如体积、钙化和 不规范。我们将在理想化的和 拟人化体模，然后将体积分析应用于 大动脉及其分支的特征化问题 血管内支架成形术治疗主动脉瘤。在 在我们的工作的临床应用阶段，我们将检验以下假设 螺旋CT血管成像的体积分析改进了计划 血管内假体部署，导致较低比例的 不良后果，并可能消除对有创动脉造影术的需要 来自部署前评估。

Modern helical CT technology, coupled with a rapid tntravenous infusion of iodinated contrast media, allows for the creation of volumetric angiograms. To date, volumetric angiograms have been visualized qualitatively with various three-dimensional rendering techniques, but a systematic, quantitative analysis of blood vessel morphology has not been conducted. Our goal is to develop and validate a method of volumetric analysis that enables quantification of cross-sectional areas of blood vessels, path lengths, curvature and branch angulation, as well as mural plaque/thrombus characteristics such as volume, calcification and irregularity. We will validate these measurements in idealized and anthropomorphic phantoms, and then apply the volumetric analysis to the problem of characterizing the aorta and its branches for the purpose of endovascular repair of aortic aneurysms with stent-grafts. In the clinical application phase of our work, we will test the hypothesis that volumetric analysis of helical CT angiograms improves planning for endovascular prosthesis deployment, leads to a lower proportion of adverse outcomes, and may obviate the need for invasive arteriography from pre-deployment evaluation.