Physiology of oxygen transport in the mammalian kidney

该项目旨在提高对肾脏组织中氧调节的理解和对肾脏生理的了解。哺乳动物的肾脏获得的氧气超过了它的使用或需要，然而肾组织通常被发现是低氧的。该项目提出，氧气向肾组织的运输受到血管表面积的限制。该项目预计将产生目前肾脏生理学领域缺乏的解剖学数据，并可能改变公认的肾脏氧稳态的故事。这将带来显著的好处，例如提供肾脏健康决定因素背后的基础生理学及其对生活质量的影响。

This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.