KINASES & EARLY RESPONSE GENES IN OROFACIAL DEVELOPMENT

组织形态学、细胞生物化学和 基因表达的调节，最终导致的起源， 面中部是多种激素和生长激素相互作用的结果 因子激活的信号通路。 很少有人关注 这些路径的特征和核事件负责 用于将短期细胞信号转换为长期表型 与正常口面发育有关的改变。 这 应用研究1）信号转导蛋白的作用 激酶C介导各种腭激素和生长的作用 2）“早期反应”核癌基因家族在 生长过程中蛋白激酶介导的信号转导， 哺乳动物次生腭的分化。

The extensive alterations in tissue morphology, cellular biochemistry and regulation of gene expression that culminate in the genesis of the midface result from the interaction of multiple hormone- and growth factor-activated signaling pathways. Little attention has been focused on characterization of these pathways and the nuclear events responsible for transducing short-term cellular signals into long-term phenotypic alterations associated with normal orofacial development. This application investigates 1) the role of the signal transducer protein kinase C in mediating the effects of various palatal hormones and growth factors and 2) the role of 'early response' nuclear oncogene families in protein kinase-mediated signal transduction during growth and differentiation of the mammalian secondary palate.