REACTION CENTER DYNAMICS

该提案要求为C。 申克。候选人的长期研究目标是 理解膜的结构和功能之间的关系 蛋白质。其他长期职业目标包括参与 营造激励性的研究生培养环境 科罗拉多州立大学生物化学和生物物理学博士后研究 大学。解决问题的多学科方法将是 很受鼓舞。迈向这些目标的第一步是开发一种 充满活力的独立研究计划。RCDA将允许候选人 全神贯注于研究和与研究相关的活动 为期五年。具体地说，RCDA将：1)减少非 与研究有关的教学和行政活动；2)允许 在两个与以下领域密切相关的研究领域发展专业知识的候选人 他自己的研究，但需要进一步的培训；3)使 通过鼓励与At的协作研究互动， 至少还有另外两名教职员工在不断增长的研究导向型 部门。 细菌反应中心是一个有趣的测试系统 生物电子转移和蛋白质动态行为的理论。 研究计划描述了候选人的短期研究目标 在此评估结构和功能之间的关系 蛋白。在五年的时间里，候选人将获得资助以1)产生 细菌反应中心的定点突变，2)特征 结构扰动的光化学效应，3)表征 用间接光谱和光电子能谱研究结构扰动的性质 生化技术和4)用物理方法解释这些观察结果 理论。

This proposal requests a Research Career Development Award for C. Schenck. The long-term research objective of the candidate is to understand the relationship between structure and function of membrane proteins. Other long term career objectives include participation in the establishment of a stimulating training environment for graduate and post-doctoral study in biochemistry and biophysics at Colorado State University. A multidisciplinary approach to problem solving will be encouraged. A first step toward these goals is the development of a vigorous independent research program. An RCDA would allow the candidate to focus complete attention on research and research-related activities for a five year period. Specifically, an RCDA would: 1) Decrease non- research related teaching and administrative activities; 2) Allow the candidate to develop expertise in two research areas closely related to his own research, but requiring further training; 3) Benefit the Department by encouraging collaborative research interactions with at least two other faculty members in a growing research-oriented department. The bacterial reaction center is an interesting system for testing theories of biological electron transfer and protein dynamic behavior. The Research Plan describes the Candidate's short-term research goals for assessing the relationships between structure and function in this protein. Over a five-year period, the Candidate is funded to 1) generate site-directed mutations in bacterial reaction centers, 2) characterize photochemical effects of structural perturbations, 3) characterize the nature of structural perturbations using indirect spectroscopic and biochemical techniques and 4) interpret these observations using physical theories.