REGIONAL VASCULAR CONTROL MECHANISMS

花生四烯酸被转化为生物活性的级联反应， 新陈代谢 这些衍生物包括环氧合酶产物，例如。 双烯前列腺素，前列环素和血栓素;以及新的 发现了脂氧合酶的代谢物，白三烯 这些脂质表现出 广泛的行动，并与各种激素系统相互作用 导致了广泛的复杂影响。 外周血管 研究了花生四烯酸和环氧合酶代谢产物的作用， 广泛地，但还没有能够牢固地建立一个作用， 这些衍生物调节外周局部血流动力学。 主要 该研究项目的目标是提高我们对 这些天然存在的物质在调节血管 阻力和血流的区域分布。 这些研究报告将 在天然血液条件下在体内动物模型中进行， 流 将使用非空心电磁流量探头测量 流 将进行研究，以确定花生四烯酸是否 在体内的坏死性水肿模型中，由于这种代谢的改变， 模型可能代表了一种新的手段，调查的功能， 花生四烯酸衍生物在循环控制中的作用。 研究还将 以确定是否形成脂氧合酶代谢物， 这种模式，以及这些衍生品是否具有能力， 参与血液动力学控制机制。 此外，潜在 三尖杉酯碱对梗阻肾血流动力学的影响 将被确定。 从这些研究中获得的总体知识将 提高我们对这些有效内源性物质的作用的理解 控制周围血管床，并应提供见解， 治疗原发性高血压等疾病。

Arachidonic acid is converted to cascade of biologically active metabolities. These derivatives include both cyclooxygenase products, eg. bisenoic prostaglandins, prostacyclin and thromboxane; as well as the newly discovered lipoxygenase metabolites, leukotrienes. These lipids exhibit a wide spectrum of actions and interact with a variety of hormonal systems resulting in a wide range of complex influences. Peripheral vascular actions of arachidonate and cyclooxygenase metabolites have been studied extensively, yet it has not been possible to firmly establish a role for these derivatives in regulation of peripheral regional hemodynamics. Major goals of the propsoed research project are to improve our understanding of the role of these naturally occurring substances in regulation of vascular resistance and regional distribution of blood flow. These studies will be carried out in in vivo animal models under conditions of natural blood flow. Noncannulating electromagnetic flow probes will be used to measure flow. Studies will be carried out to determine whether arachidonic acid metabolism is altered in an in vivo model of hydroneohrosis, since such a model may represent a novel means of investigating the function of arachidonic acid derivatives in circulatory control. Studies will also be carried out to determine whether lipoxygenase metabolites are formed in this model, and whether these derivatives possess the capacity to participate in hemodynamic control mechanisms. Additionally, potentially altered hemodynamic influnces of prostaglandins in the obstructd kidney will be determined. Overall knowledge gained from these studies will improve our understanding of the role of these potent endogenous substances in control of the peripheral vascular bed, and should provide insights into treatment of diseases such as essential hypetension.