Upconversion nanothermometry: enabling high brightness in a thermal field

该项目旨在通过研究增强光子能量转换的新观察，为生物发现、疾病诊断、设备制造和防伪创建一个独特的纳米级温度响应传感器库。该项目将开发一种热场诊断方法来揭示发光杂化纳米材料的界面阳离子配体行为，并修改其他猝灭分子以促进能量上转换。这将把表面化学和非均相界面物理联系起来。它将允许比例荧光在细胞内纳米热测量中实现极高的传感灵敏度，从而实现活细胞的超分辨率热成像。

This project aims to create a unique library of nanometer scale temperature-responsive sensors for bio-discoveries, disease diagnostics, device manufacturing and anti-counterfeiting, by investigating a new observation in enhanced photon energy conversion. The project will develop a thermal-field diagnostics approach to reveal interfacial cation-ligand behaviours of luminescent hybrid nanomaterials, and modify the otherwise quenching molecules to facilitate energy upconversion. This will link surface chemistry and heterogeneous interfacial physics. It will allow ratiometric fluorescence to achieve extremely high sensing sensitivity in intracellular nanothermometry, enabling super resolution thermal imaging of living cells.