IN-UTERO COCAINE EXPOSURES--NEURODEVELOPEMENT

可卡因是怀孕预兆和日益增长的 由于对后代的风险，人们对公共卫生感到担忧。在 新生儿期，包括低出生体重和神经行为 异常现象。到目前为止，还没有关于 宫内接触可卡因儿童的神经发育。 我们建议评估暴露于核辐射中的新生儿的神经结局。 宫内可卡因。该队列将包括约300名婴儿，约150名 从纽约一家医院招募的150名暴露于可卡因的人和150人未暴露的人 两年多了。怀孕期间的接触状况将通过以下方式确定 尿毒学结果图表摘要，面谈自我报告， 和/或可卡因代谢物的母体毛发提取液。此外，我们还使用 现有的数据集，围产期艾滋病毒传播神经发育 附加研究(Pi，Maria Suarez博士)，以分析宫内影响 可卡因暴露对未感染儿童神经发育结局的影响。 第一个目标将是确定宫内可卡因的效果 出生时对结局的暴露：头部大小、胎龄、宫内 生长和神经状态。数据将从人体测量中提取 测量、妊娠评估、神经学检查和图表 抽象。第二个目标将是确定子宫内是否 可卡因暴露与神经行为风险增加有关 儿童的损害一直持续到三岁。 两组婴儿(暴露和未暴露)之间的对比将 评估不良结果或损害的风险是否特定于 接触可卡因的婴儿，或类似于传递给类似 种族和社会经济地位。

Cocaine is the primary illicit drug used by pregnant omen and a growing public health concern because of the risks to the offspring. In the neonatal period, these include low birth weight and neurobehavioral abnormalities. There are to date, no systematic data on the neurodevelopment of children exposed in-utero to cocaine. We propose to evaluate the neurological outcome of neonates exposed to cocaine in-utero. The cohort will comprise about 300 infants, about 150 cocaine-exposed and 150 unexposed, recruited from a single NYC hospital over 2 years. Exposure status during pregnancy will be ascertained by chart abstraction for urine toxicology results, self report by interview, and/or maternal hair extract for cocaine metabolites. In addition, we use an existing data set, the Perinatal HIV Transmission Neurodevelopment Add-On study (PI, Dr. Maria Suarez), to analyze the effects of in-utero cocaine-exposure on neurodevelopment outcome in uninfected children. A first objective will be to determine the effect of intrauterine cocaine exposure on outcomes at birth: head size, gestational age, intrauterine growth, and neurological status. Data will be drawn from anthropometric measures, gestational assessments, neurological examinations, and chart abstraction. A second objective will be to determine whether in-utero cocaine exposure is associated with an increased risk of neurobehavioral impairment in children followed until age three. Contrasts between the two groups of infants (exposed and unexposed) will assess whether the risk for adverse outcome or impairment is specific to cocaine-exposed infants, or similar to that conveyed to infants of similar racial and socioeconomical status.