MOTOR & LIMBIC SYSTEM INTEGRATION IN SCHIZOPHRENIA

这个NIMH医生科学家奖的目的是获得技能， 独立研究员，探索神经解剖学基础， 精神分裂症基底神经节在介导整合中的作用 不同的输入形成运动、联合和边缘相关的皮层， 基底神经节内的错误整合如何表现在 将研究精神分裂症患者的复杂精神病学。 的 腹侧纹状体和苍白球，可能代表部分的基底 运动神经节和边缘相关通路的整合发生的神经节， 由于它们与两个功能区域的连接。 奖学金计划的第一阶段（1-2年）涉及一般性的 神经解剖学、神经生理学和 神经内分泌学和有关神经科学一般主题的研讨会 和基底神经节功能。 介绍性的研究经验将是 通过与哈伯博士在持续和独立的实验室工作获得 实验的中心是研究边缘系统和运动系统的整合， 基底神经节的相关通路。 培训计划的第二阶段（3-5年）包括 独立实验，最初在啮齿动物中进行，旨在探索其作用 腹侧苍白球的传出投射作为潜在的介质 边缘系统和运动神经整合的机制， 整合发生。 这些实验将探索 背侧（运动）和腹侧（边缘）苍白球到 黑质、丘脑底核和腹侧被盖区; 腹侧苍白球传出纤维对脑内细胞的侧支化 腹侧苍白球投射到边缘和非边缘区域。 顺行示踪剂（PHAL，滴定氨基酸，WGAS-HRP）和逆行示踪剂 示踪剂（荧光染料，WGA-HRP）与肽的组合， 酪氨酸羟化酶免疫细胞化学将用于这些 实验

The purpose of this NIMH Physician Scientist Award is to gain skills as an independent researcher to explore the neuroanatomic basis of schizophrenia. the role of the basal ganglia in mediating integration of diverse inputs form motor-, association-, and limbic-related cortices and how faulty integration within the basal ganglia may be manifest in the complex symptomatology of schizophrenic patients will be studied. The ventral striatum and globus pallidus, may represent portions of the basal ganglia where integration of motor- and limbic-related pathways occurs by virtue of their connections to both functional regions. The Phase I portion (years 1-2) of the fellowship program involves general graduate coursework in neuroanatomy, neurophysiology, and neuroendocrinology and seminars concerning general topics in neuroscience and basal ganglia function. Introductory research experience will be obtained by working with Dr. Haber on ongoing and independent laboratory experiments which center on examining the integration of limbic and motor- related pathways of the basal ganglia. The Phase II portion (years 3-5), of the training program involves independent experiments, initially in rodents, designed to explore the role of the efferent projections of the ventral pallidum as potential mediators of limbic and motor integration and the mechanisms by which this integration occurs. These experiments will explore the differential projections of dorsal (motor) and ventral (limbic) pallidum to the substantia nigra, subthalamus nucleus and ventral tegmental area; whether collateralization of ventral pallidal efferent fibers to cells in the ventral pallidum which project to limbic and non-limbic regions. Anterograde tracers (PHAL, titrated amino acids, WGAS-HRP) and retrograde tracers (fluorescent dyes, WGA-HRP) in combination with peptide and tyrosine hydroxylase immunocytochemistry will be utilized in these experiments.