BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

几位研究人员最近对不同问题的研究 在我们的实验室已经显示了新的磁共振成像技术， 对磁化率效应敏感，可以提供独特的 关于潜在病理解剖结构的信息， 常规MR成像无法获得的生理学 方法. 两大类磁化率效应 被证明是重要的。 1)内源性铁的变化 灌注敏感显微镜 顺磁性药物给药后的敏感性变化 造影剂。 本计划项目补助金的目的是 规定对下列问题进行协调调查： 这些效应对于提高利用率和改善 MR成像在多种器官系统中的诊断特异性 和病理状态，包括癌症、缺血、出血和 血栓形成 该项目分为五个研究项目， 每一个都专注于一个单独的问题，但共享核心资源， 方法和人员有相当大的重叠， 建设性的互动。 这五个方面是：1）正常、缺血和 肿瘤组织的瞬时磁化率 顺磁性造影剂的作用和对固有 毛细血管中流动的影响; 2）正常和 基于磁化率效应的缺血心肌，以及 顺磁性造影剂的相关性效应; 3)出血的系列多核MR成像， EPR和组织病理学相关; 4）磁化率- 深静脉血栓形成的敏感和流动敏感成像， 生化相关性; 5）各种对照的比较 使用常规和磁性磁化率敏感的试剂 成像技术的最佳检测和表征 肝转移 这些项目得到三个核心项目的支持。 实验室：核磁共振核心计算机和技术核心，对比 代理核心和管理核心。

Recent work by several investigators working on different problems in our laboratory has shown the novel MR imaging techniques which are sensitive to magnetic susceptibility effects can provide unique information about the underlying pathological anatomy and physiology that cannot be obtained with conventional MR imaging methods. Two broad classes of magnetic susceptibility effects have been shown to be important. 1) alterations in endogenous iron content and biochemistry and 2) perfusion sensitive microscopic susceptibility variations following administration of paramagnetic contrast agents. The purpose of this Program Project Grant is to provide for a coordinated investigation for the implications of these effects for enhancing the utilization and improving the diagnostic specificity of MR imaging in a variety of organ systems and pathological states, including cancer, ischemia, hemorrhage and thrombosis. This proposal is divided into five research projects, each focused on a separate problem but sharing Core resources and with considerable overlap of methodologies and personnel to allow for constructive interaction. The five are: 1) MR brain studies of normal, ischemic and neoplastic tissues bases on transient magnetic susceptibility effects of paramagnetic contrast agents and on the intrinsic effects of flow in capillaries; 2) MR studies in normal and ischemic myocardium based on magnetic susceptibility effects, and also on the relativity effects, of paramagnetic contrast agents; 3) Serial multinuclear MR imaging of hemorrhage with biochemical, EPR and histopathologic correlates; 4) Magnetic susceptibility- sensitive and flow-sensitive imaging of deep venous thrombosis with biochemical correlation; and 5) Comparison of various contrast agents using conventional and magnetic susceptibility-sensitive imaging techniques for optimal detection and characterization of liver metastases. These projects are supported by three Core laboratories: NMR Core Computer and Technologies Core, Contrast Agent Core, and an Administrative Core.