BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

几名研究人员最近针对不同问题所做的工作 在我们的实验室展示了新的磁共振成像技术， 对磁化率敏感的效应可以提供独特的 关于潜在的病理解剖和 常规磁共振成像无法获得的生理功能 方法：研究方法。磁化率效应有两大类 已经被证明是重要的。1)内源性铁的变化 含量和生化；2)灌注敏感显微镜 顺磁给药后的磁化率变化 造影剂。本计划项目赠款的目的是 为以下方面的影响提供协调调查 这些对提高利用率和改善环境质量的作用 磁共振成像对多种器官系统的诊断特异性 以及病理状态，包括癌症、缺血、出血和 血栓形成。这项提案分为五个研究项目， 每个人都专注于一个单独的问题，但共享核心资源和 方法和人员有相当大的重叠，以允许 进行建设性的互动。 这五项研究包括：1)正常、脑缺血和脑缺血的磁共振脑研究 基于瞬时磁化率的肿瘤组织 顺磁性对比剂的作用及对本征的影响 毛细血管内流动的影响；2)正常和 基于磁化率效应的缺血心肌，以及 顺磁性造影剂的相对性效应； 3)连续多核生化出血磁共振成像， EPR与组织病理学的相关性；4)磁化率- 深静脉血栓形成的敏感和血流敏感成像 生化相关；5)不同对比的比较 使用常规和磁敏性的试剂 用于最佳检测和表征的成像技术 肝脏转移。这些项目由三核支持 实验室：核磁共振核心计算机和技术核心，对比 代理核心和管理核心。

Recent work by several investigators working on different problems in our laboratory has shown the novel MR imaging techniques which are sensitive to magnetic susceptibility effects can provide unique information about the underlying pathological anatomy and physiology that cannot be obtained with conventional MR imaging methods. Two broad classes of magnetic susceptibility effects have been shown to be important. 1) alterations in endogenous iron content and biochemistry and 2) perfusion sensitive microscopic susceptibility variations following administration of paramagnetic contrast agents. The purpose of this Program Project Grant is to provide for a coordinated investigation for the implications of these effects for enhancing the utilization and improving the diagnostic specificity of MR imaging in a variety of organ systems and pathological states, including cancer, ischemia, hemorrhage and thrombosis. This proposal is divided into five research projects, each focused on a separate problem but sharing Core resources and with considerable overlap of methodologies and personnel to allow for constructive interaction. The five are: 1) MR brain studies of normal, ischemic and neoplastic tissues bases on transient magnetic susceptibility effects of paramagnetic contrast agents and on the intrinsic effects of flow in capillaries; 2) MR studies in normal and ischemic myocardium based on magnetic susceptibility effects, and also on the relativity effects, of paramagnetic contrast agents; 3) Serial multinuclear MR imaging of hemorrhage with biochemical, EPR and histopathologic correlates; 4) Magnetic susceptibility- sensitive and flow-sensitive imaging of deep venous thrombosis with biochemical correlation; and 5) Comparison of various contrast agents using conventional and magnetic susceptibility-sensitive imaging techniques for optimal detection and characterization of liver metastases. These projects are supported by three Core laboratories: NMR Core Computer and Technologies Core, Contrast Agent Core, and an Administrative Core.