NEUROENDOCRINOLOGY OF REPRODUCTION AND GROWTH

一项计划项目，提出：1)完成分离，分子 一种新的垂体和胎盘蛋白的性质和合成， 牛和人体内存在的中营养因子或中胚层生长因子(MGF) 脑垂体和人胎盘；2)确定MGF的生物学和作用 黄体功能、着床与胎儿发育；3) 阐明下丘脑控制MGF分泌的本质 我们已经证明了它的存在；4)完成隔离， 卵泡液来源的抑制素的表征和合成；5) 确定卵泡抑制素的生物学特性(S)；6)阐明其性质 卵泡肽调节卵泡对促性腺激素的敏感性； 7)使用合成GRF(生长激素)进行生理学研究 体内和体外释放因子或生长抑素)；8)分离， 鉴定和合成与促肾上腺皮质激素相关的垂体素 控制青春期肾上腺雄激素生成；9)提高对 目前多肽的表征方法；10)保持 或扩展目前的多肽合成方法；11)保持 并扩展目前的放射免疫分析方法和 免疫技术；后三个项目作为核心支助的一部分 该计划。

A Program Project which proposes: 1) To complete the isolation, molecular characterization and synthesis of a novel pituitary and placental protein, mesotrophin, or mesodermal growth factor (MGF) present in bovine and human pituitaries and human placenta; 2) To ascertain the biology and role of MGF in function of the corpus luteum, implantation and fetal developmnt; 3) To elucidate the nature of the hypothalamic control of the secretion of MGF which we already have demonstrated to exist; 4) Complete the isolation, characterization and synthesis of inhibin of follicular fluid origin; 5) To ascertain the biology of follicular inhibin(s); 6) To elucidate the nature of follicular peptides regulating follicular sensitivity to gonadotropins; 7) To pursue physiological studies with synthetic GRF (growth hormone releasing factor or somatocrinin), in vivo and in vitro; 8) To isolate, characterize and synthesize pituitary factors (other than ACTH) involved in control of pubertal adrenal androgenesis; 9) To improve the sensitivity of the current methodology for characterization of peptides; 10) To maintain or expand the current methodology for peptide synthesis; 11) To maintain and expand the current methodology for radioimmunoassays and immunotechniques; the latter three projects as part of core supports within the Program.