Movement of mitochondria between cells

该项目旨在研究线粒体如何在细胞之间移动到线粒体功能障碍的移植细胞中。线粒体如何到达受体细胞以及它们如何从供体细胞移动尚不清楚。该项目将采用“自下而上”的方法，从重组系统开始，经过体外共培养阶段，再到相关的生物模型，增加复杂性和生物相关性。它将证明线粒体细胞间运动的过程依赖于细胞间桥和特定的运动系统。该项目与细胞生物学高度相关。

This project aims to characterise how mitochondria move between cells into grafted cells with dysfunctional mitochondrial function. How mitochondria reach the acceptor cell and how they move from the donor cell is not known. The project will use a 'bottom-up' approach, starting from a reconstituted system, via in vitro, co-culture stage to a relevant biological model, increasing complexity and biological relevance. It will document that the process of mitochondrial intercellular movement is dependent on intercellular bridges and a specific mobility system. The project is of high relevance for cell biology.