REPRODUCTIVE BIOLOGY IN PRIMATES: CENTER FACILITIES

这是人口中心奖助金的竞争性续签申请 来自俄勒冈州区域灵长类研究中心(ORPRC)的 请求为核心服务提供支持，以促进个人研究 具有合格的NICHD任务目标的计划。核心支持是 要求进行放射免疫分析和生物分析(RIA)、形态学(MOR) 包括电子显微镜和原位杂交，细胞培养 (CC)试剂、未受精和受精配子(试管受精-EE)，包括 转基因动物，以及项目管理(ADM)。这项研究 小组由至少21名调查人员(PI)组成，并获得适当资金 世卫组织利用多学科方法研究灵长类 繁殖。 积极研究的具体领域包括：神经内分泌事件 青春期前后对垂体-性腺轴的影响 成人；脑和生殖道中的类固醇激素机制； 月经周期和妊娠的内分泌生理学.控制 精子活力；体内和体外受精；基因组过程 阿片肽在肾上腺素能受体中的表达和功能； 生殖光周期；神经和神经中的旁分泌因子 生殖组织；以及衰老过程中神经和内分泌的变化。 这些设施的存在将加强 并防止不必要的设备重复， 人员和技术。

This is a competitive renewal application for a Population Center Grant (P30) from the OREGON REGIONAL PRIMATE RESEARCH CENTER (ORPRC) that requests support for core services to facilitate individual research programs with qualified NICHD mission objectives. Core support is requested for radioimmunoassays and bioassays (RIA), morphology (MOR) including electron microscopy and in situ hybridization, cell culture (CC) reagents, unfertilized and fertilized gametes (IVF-EE) including transgenic animals, and for program administration (ADM). The research group comprises at least 21 investigators (PIs) with appropriate funding who utilize multidisciplinary approaches for the study of primate reproduction. Specific areas of active research include: neuroendocrine events influencing the hypophyseal-gonadal axis during peripuberty and in adults; steroid hormone mechanisms in the brain and reproductive tract; endocrine physiology of the menstrual cycle and pregnancy; control of sperm motility; in vivo and in vitro fertilization; genomic processes in opiate peptide expression and in adrenergic receptor function; reproductive photoperiodicity; paracrine factors in neural and reproductive tissues; and neural- ana endocrine changes during aging. The existence of these facilities will enhance collaboration among members of these units and prevent unnecessary duplication of equipment, personnel and technologies.