CENTER FOR REPRODUCTIVE BIOLOGY RESEARCH

这项提议的总体目标是继续支持 范德比尔特大学现有的跨部门、多学科 人口研究中心。中心的持续支持将 保持许多与人口有关的项目的效率，目前活跃在 范德比尔特，并将允许在目前未开发的新地区进行开发 有代表性的。该中心的研究目标包括调查 关于男性生殖生理(精子产生、精子生物化学、 精子代谢、精子成熟、精子获能、男性发育 避孕和男性性行为的神经内分泌控制)，关于 女性生殖生理学(受精和植入) 生殖内分泌学(生殖激素结构、合成、 新陈代谢和作用机制)，以及生殖病理学 (淋病引起的女性不孕症和女性不孕症恶变 人类乳腺)。请求为行政核心单位提供支助 和八个核心设施(组织学和光学显微镜、电子学 显微镜，组织培养，环核苷酸，前列腺素，激素 化验、有机化学、单抗)。

The overall objective of this proposal is to continue the support at Vanderbilt University of an existing interdepartmental, multidisciplinary Population Research Center. The continuous support of the Center will maintain the efficiency of many population related projects now active at Vanderbilt and will permit development in new areas not presently represented. The research objectives of the Center include investigations on male reproductive physiology (sperm production, sperm biochemistry, sperm metabolism, sperm maturation, sperm capacitation, development of male contraception, and neuroendocrine control of male sexual behavior), on female reproductive physiology (fertilization and implantation), on reproductive endocrinology (reproductive hormones structure, synthesis, metabolism, and mechanism of action), and on reproductive pathology (gonococcal-induced female infertility and malignant transformation of the human mammary gland). Support is requested for an administrative core unit and eight core facilities (Histology & Photomicroscopy, Electron Microscopy, Tissue Culture, Cyclic Nucleotide, Prostaglandin, Hormone Assay, Organic Chemistry, Monoclonal Antibody).