SPECIALIZED MATERIALS SCIENCE RESEARCH CENTER

该中心建议的主要目标是雇用高 技术概念，仪器和计算机支持，以开发 用于诊断、治疗和分析的材料和分析系统 恢复性应用。需要探讨的概念领域之一是 元素或化合物从粘合剂中的受控释放， 界面膜、表面涂层、腔体制备衬垫和根部 根管封闭剂用作：1）下面的龋齿活动的标记物 2）氟化物的时间释放源，3）钙化 解决方案，以使龋组织，4）缓冲液和抗菌 在龋环境中改变细菌活性的试剂，和5） 用于增强闭合和愈合的生物活性界面材料 骨质缺损和暴露的牙髓组织。最近的突破 聚合物微球技术，微胶囊技术， 溶胶-凝胶法制备生物活性陶瓷， 含控释剂的创新牙科材料。这些 材料应通过最小化 由于龋齿诊断的不确定性， 位置位于沿着牙齿修复界面，通过减少 与现有龋齿相关的复发性龋齿或龋齿进展的风险 根管治疗是一种有效的治疗方法。另一 创新的方法将需要立体摄影测量的应用 用于定量分析的自动化分析系统的开发技术 生物和假体材料上发生的形貌变化 表面。从双摄像机系统获得的图像的立体对，或 扫描电子显微镜将被光学数字化并存储为 从表面的地形图中提取的计算机图像文件。自动化 立体摄影测量系统可用于开发CAD-CAM加工 假体的磨损或化学降解率， 牙齿和修复材料。另一个有待探索的新概念 涉及开发一种可浇铸的玻璃陶瓷， 通过着色剂元素的相互作用控制着色 或氧化物和热处理。目前可用的可浇铸陶瓷 只能在外面涂上一层遮光瓷 并且在某些情况下，通过使用着色水泥。长期研究 该中心计划的目标是：1）建立最佳配方 以及开发聚合物微球的加工技术， 用于广谱诊断和治疗的微胶囊递送系统 治疗剂，2）开发修复树脂， 控制剂量的氟化物或其他治疗剂， 在预计的使用寿命内， 修复体或器具，3）确定生物活性的功效， 通过溶胶-凝胶技术处理的玻璃， 组织和促进牙髓和根尖周区域的伤口愈合，4） 发展自动立体摄影测量系统， 牙齿结构和牙列的地形变化，以及5） 开发和评估Li 2 O-CaO-Al 2 O3-SiO2系列的性能 具有内部着色控制的玻璃陶瓷。

The principal objective of this Center proposal is to employ high technology concepts, instrumentation, and computer support to develop materials and analytical systems for diagnostic, therapeutic, and restorative applications. One of the conceptual areas to be explored is the controlled release of elements or compounds from bonding agents, interfacial films, surface coatings, cavity preparation liners, and root canal sealers to serve as: 1) markers of caries activity below restorations, 2) time-release sources of fluoride, 3) calcifying solutions to remineralize carious tissue, 4) buffers and antibacterial agents to alter bacterial activity in carious environments, and 5) bioactive interfacial material used to enhance closure and healing of osseous defects and exposed pulp tissue. Recent breakthroughs in the technology of polymer microspheres, microencapsulation techniques, and sol-gel processing of bioactive ceramics will be used to develop innovative dental materials containing controlled-release agents. These materials should extend the life expectancy of restorations by minimizing their premature replacement due to the uncertainty in caries diagnosis in sites which lie along the tooth-restoration interface, by reducing the risk for recurrent caries or caries progression associated with existing restorations, and by minimizing the need for endodontic therapy. Another innovative approach will entail the application of stereophotogrammetric technology to develop in automated analytical system for quantifying topographical changes that occur on biological and prosthetic material surfaces. Stereopairs of images derived from a two-camera system or scanning electron microscope will be optically digitized and stored as image files in a computer from topographic maps of surfaces. Automated stereophotogrammetric systems can be used to develop CAD-CAM processed prostheses and to evaluate wear or chemical degradation rates of natural teeth and restorative materials. Another novel concept to be explored involves the development of a castable glass-ceramic with internal coloration controlled through the interactive effect of colorant elements or oxides and thermal processing. Currently available castable ceramics can only be shaded by applying an external layer of shading porcelain and, in some cases, by using pigmented cements. The long-range research goals of this Center program are: 1) to establish optimum formulations and processing techniques for development of polymer microsphere and microcapsule delivery systems for a broad spectrum of diagnostic and therapeutic agents, 2) to develop restorative resins which deliver a controlled dose of fluoride or other therapeutic agents without appreciable structural degradation over the projected lifetime of the restoration or appliance, 3) to establish the efficacy of bioactive glasses processed by sol-gel technology which form direct interfaces with tissue and promote wound healing in pulpal and periapical areas, 4) to develop an automated stereophotogrammetric system for mapping topographical changes on tooth structure and restorations, and 5) to develop and assess the performance of a family of Li2O-CaO-Al2O3-SiO2 glass-ceramics with internal coloration control.