MULTIPURPOSE ARTHRITIS CENTER

该提案详细说明了扩大和加强 波士顿大学多功能关节炎中心。 活动计划 具体项目将在三个主要部分进行：研究， 教育和社区/卫生服务研究。 该提案还 描述了一项计划，以支持特殊研究兴趣的领域， 两个核心单位，并继续有效的行政组成部分。 研究部分将建立在由以下方面资助的坚实的工作基础上： 其他来源 此外，还进行了四项发展和可行性研究， 建议：1）前白蛋白形式的维生素A代谢的研究， 淀粉样蛋白疾病; 2）血清淀粉样蛋白A的cDNA克隆的分离; 3） 关节炎患者爬楼梯的研究; 4） 功能评估中的难度维度。 MAC教育工作将继续针对广泛的 关节炎健康专业人员与医学院， 波士顿大学护理学与联合健康课程。 具体 教育部分的项目将包括对 内务部军官风湿病学教育现状 医学和家庭实践住院医师计划，一项关于 针对性的物理治疗人际交往技能培训计划 慢性关节炎患者应对方式的调查。 MAC的社区/高铁部分的活动将继续侧重于 与卫生部合作， 和波士顿市的医院。 七个具体的社区/保健 服务研究项目建议：1）项目修改 用于临床实践的关节炎影响测量量表; 2）a 发展一个电脑社区网络， 流变学试验; 3）市中心疗养院项目， 为这一重要群体开展外联和数据收集工作; 4）研究 普通内科医生及家属的风湿病转诊行为 5）骨关节炎的流行病学研究， 与心脏病研究; 6）口服的流行病学研究 避孕药和类风湿性关节炎与既定的 药物流行病学组;（7）调查的关系 类风湿性关节炎中压力性生活事件与疾病活动之间的关系。 建议两个核心单位：淀粉样蛋白研究核心单位和研究 和评价支助核心股。 这些核心单元将支持许多 对本中心特别感兴趣的领域进行调查。

This proposal describes in detail a plan to expand and strengthen the Boston University Multipurpose Arthritis Center. A program of activities and specific projects will be pursued in 3 major components: Research, Education and Community/Health Services Research. The proposal also describes a plan to support areas of special research interest by means of two Core Units, and to continue an effective Administration Component. The Research Component will build on a strong base of work funded from other sources. In addition, four Developmental and Feasibility studies are proposed: 1) a study of vitamin A metabolism in prealbumin forms of amyloid disease; 2) the isolation of cDNA clones for serum amyloid A; 3) an investigation of stair climbing in arthritis; and 4) a study of the difficulty dimension in functional assessments. MAC education efforts will continue to be aimed at a broad spectrum of arthritis health professionals in conjunction with the Schools of Medicine, Nursing and Allied Health Professions of Boston University. Specific projects in the education component will include an evaluation of the current status of house officer education in rheumatology at internal medicine and family practice residency programs, a study of the effects of a targeted training program on interpersonal skills of physical therapy students and an investigation of coping in chronic arthritis. Activities in the Community/HSR component of the MAC will continue to focus on the inner-city community in conjunction with the Department of Health and Hospitals of the City of Boston. Seven specific community/health services research projects are proposed: 1) a project to modify the Arthritis Impact Measurement Scales for use in clinical practice; 2) a project to develop a computer-based community network for clinical rheumatology trials; 3) a inner-city nursing home project combining outreach and data collection for this important population; 4) a study of the rheumatology referral behavior of general internists and family practitioners; 5) an epidemiologic study of osteoarthritis in conjunction with the Framingham Heart Study; 6) an epidemiologic study of oral contraceptives and rheumatoid arthritis in conjunction with an established drug epidemiology group; and (7) an investigation of the relationship between stressful life events and disease activity in rheymatoid arthritis. Two Core Units are proposed: an Amyloid studies Core Unit and a Research and Evaluation Support Core Unit. These Core Units will support numerous investigations in areas of special interest to this Center.