PATHOPHYSIOLOGY OF PRESBYACUSIS

实验提出调查的一些 发生在外周听觉的生理变化 系统作为老化的结果在一个安静的环境和老化， 低噪音的环境。 我们的主要目标是确定 耳蜗中的一些机制会随着年龄的增长而退化 慢性噪音暴露。 初步结果表明 耳蜗管沿着离子泵组织功能障碍 可能是导致某些类型的听力损失的原因， 年龄 还建议进行研究，以检查年龄的一些影响 和噪声对耳蜗核中的二级神经元的影响。 耳蜗核研究的目的是开始 研究中枢神经系统如何对长期的 低水平的噪音。 建议的工作有直接 对人类研究的影响， 听力通常在老年人中发现，这一过程被称为 老年性聋 在受控动物中进行的系统性研究 条件将提供一个检验各种假设的机会 年龄和环境如何相互作用， 听觉系统

Experiments are proposed to investigate some of the physiological changes that take place in the peripheral auditory system as the result of aging in a quiet environment and aging in an environment of low-level noise. Our major goal is to identify some of the mechanisms in the cochlea that deteriorate with age and chronic noise exposure. Preliminary results suggest that dysfunction in the ion-pumping tissue along the cochlear duct may be responsible for certain types of hearing loss seen with age. Studies are also proposed to examine some effects of age and noise on the second-order neurons in the cochlear nucleus. The purpose of the cochlear nucleus studies is to begin to examine how the central nervous system responds to long-term low-level exposures of noise. The proposed work has direct bearing on human studies concerned with the gradual loss of hearing often found in the elderly, a process termed presbyacusis. Systematic studies in animals under controlled conditions will provide an opportunity to test various hypotheses of how age and environment interact to change the peripheral auditory system.