ELASTICITY--FORCE & FIBER LENGTH CHANGES IN AGING MUSCLE

这里描述的是一个多学科的项目，旨在阐明 细胞机制参与血管内皮细胞的蓄积和重塑 肌肉结缔组织和运动范围减少发生在 老龄化和/或不活跃的个人。第一个假设是， 并影响肌腹结缔组织的特性 根据肌肉所受的活动类型和伸展 这是一个重要因素。第二个假设是结缔组织 重塑与肌节数量的调整有关，因此有 运动范围缩小，僵硬程度增加。 被问到的问题包括：有规律的锻炼能延缓高血压的发病吗？ 通过改变结缔组织的分布和性质而使肌肉僵硬 组织？还有，哪种类型的伸展(主动、被动、动态)是主要的 防止肌肉结缔组织积聚和肌节形成的因素 损失？ 肌肉结缔组织的形式和数量将通过 定量透射法、EM和光学显微镜技术。变化 将评估肌内和肌周结缔组织中的 胶原蛋白和收缩蛋白的合成速度将被测量到 阐明了重塑过程。函数长度的变化 肌肉纤维将通过测量肌节数和 肌节长度。加法和加法所涉及的细胞机制 移除肌节的研究将与参与的研究同时进行 结缔组织重塑和这些将与物理和 研究了肌肉的生理特征。这些措施包括 测量肌肉力量、力量发展速度、顺应性和 弹性。形态和生理上的变化都将是 与的运作(部队生产、遵从性和弹性)有关 老化的肌肉骨骼系统。 这些数据应该对那些参与物理研究的人有相当大的价值 治疗，老年呼吸科、骨科和神经科的管理 患者以及一般的老年患者。

Described here is a multidisciplinary program which is aimed at elucidating the cellular mechanisms involved in the accumulation and remodeling of muscle connective tissue and the reduced range of movement that occur in aging and/or inactive individuals. The first hypothesis is that the amount and properties of the connective tissue in the muscle belly are influenced by the type of activity that the muscle is subjected to and that stretch is the important factor. The second hypothesis is that connective tissue remodeling is linked with adjustments in sarcomere number so that there is a reduced range of movement as well as an increase in stiffness. The questions asked include: can regular exercise delay the onset of muscle stiffness by altering the distribution and nature of the connective tissue?; also, which type of stretch (active, passive, dynamic) is the main factor in preventing muscle connective tissue accumulation and sarcomere loss? The form and amount of muscle connective tissue will be studied by quantitative transmission, EM, and light microscopic techniques. Changes in endomysial and perimysial connective tissue will be evaluated and the rates of synthesis of collagen and contractile proteins will be measured to shed light on the remodeling process. Changes in the functional length of muscle fibers will be determined by measuring sarcomere number and sarcomere length. The cellular mechanisms involved in the addition and removal of sarcomeres will be studied concurrently with those involved in connective tissue remodeling and these will be related to the physical and physiologic characteristics of the muscles studied. These will include measurements of muscle force, rate of force development, compliance and elasticity. Both the morphologic and physiologic changes will then be related to the functioning (force production, compliance and elasticity) of the aging musculoskeletal system. The data should be of considerable value to those involved in physical therapy, the management of elderly respiratory, orthopedic and neurologic patients as well as elderly patients in general.