REGIONAL CEREBRAL BLOOD FLOW IN AGING AND DEMENTIA

本提案的目标是使用133Xe吸入法 测量局部脑血流量(RCBF)以研究大脑行为 正常老年人与阿尔茨海默病患者的关系 本病起病为老年性、多发性梗死性痴呆和抑郁症。在.期间 项目的第一年和第二年，感觉运动和认知调节 激活大脑半球和局部脑血流，以及 影响正常老年人激活水平和模式的变量 受试者将接受调查。在项目的第三年， 脑血流和认知功能的相伴变化 阿尔茨海默病患者起病为老年性、多发性梗死性痴呆、 抑郁症，并在正常老年受试者中进行调查。完成 将提供对133Xe的效用的确认 吸入法在大脑皮层病变诊断中的应用 与老年有关的痴呆症。它将另行规定 关于这些过程对大脑的影响的无法获得的信息 在老年人口中发挥作用。

The objective of the present proposal is to use the 133Xe inhalation method of measuring regional cerebral blood flow (rCBF) to study brain behavior relations in normal aged individuals and in patients with Alzheimer's disease of senile onset, multi-infarct dementia and depression. During years 1 and 2 of the project, sensorimotor and cognitively mediated activation of hemispheric and regional cerebral blood flow, and the variables which affect the level and pattern of activation, in normal aged subjects will be investigated. During the third year of the project, the concomitant changes in cerebral blood flow and cognitive functions in patients with Alzheimer's disease of senile onset, multi-infarct dementia, depression, and in normal aged subjects will be investigated. Completion of the project will provide confirmation of the utility of the 133Xe inhalation method as a diagnostic tool in the study of the cortical dementias associated with the senium. It will provide otherwise unobtainable information about the effect of these processes on brain functioning in the geriatric population.