Moonlighting functions of endocytic proteins during the cell cycle

细胞可以被认为是孤岛--它们与外界隔绝，因为它们有一层质膜，不让任何东西通过。然而，细胞已经进化出微小的门户，让东西以严格管制的方式进入。这些门户一直在工作，但当细胞需要分裂时，它们会被关闭。重要的是，目前不能犯任何错误。否则，细胞可能会死亡，或者开始以一种不寻常的方式生长，导致疾病，例如癌症。没有人知道这种停摆是如何发生的。我们想要使用一台机器来研究门户，它可以告诉我们组成门户的所有部件。如果我们比较正常细胞和那些正在分裂的细胞的入口，这将告诉我们在分裂细胞中缺少哪些片段。然后我们可以找出细胞在细胞分裂开始时是如何将这些片段带走的。我们认为这项工作很重要。这些门户被病毒劫持：它们将门户用作感染细胞的一种方式。如果我们知道细胞是如何关闭传送门的，我们就可以想出用药物关闭传送门的方法。这些药物可用于抗病毒治疗。

Cells can be thought of as islands - they are closed to the outside world because they have a plasma membrane that doesn't let anything through. However, cells have evolved tiny portals for things to enter in a tightly regulated way. These portals are working all the time, but they are shut down when the cell needs to divide. It is important that no mistakes are made at this time. Otherwise the cell could die or it could start to grow in an unusual way leading to disease e.g. cancer. Nobody knows how this shutdown happens. We want to study the portals using a machine that can tell us all the pieces that make up a portal. If we compare portals from normal cells with those that are dividing this will tell us which pieces are missing in dividing cells. We can then find out how the cell takes these pieces away at the start of cell division. We think that this work is important to do. These portals are hijacked by viruses: they use portals as a way to infect cells. If we knew how the cell shuts down the portals, we could think of ways to switch them off using drugs. These drugs could be used as anti-viral treatments.