BLOOD PRESSURE AND TEMPERATURE IN AGING

长期目标：本项目旨在定义 心血管系统的标准化老化 血压和核心体温的动态分析 24小时动态监测观察变化。超级市场 将测试收缩压(SBP)的节律作为标志物 年龄在60岁或以上的健康老年人的正常年龄 在社区里过着活跃的生活。线性化和线性化方法 非线性光谱学将用于提取昼夜节律和 超乎寻常的节奏。我们的具体目的是检验这一假说 这种内在的老化导致了时间组织的转变 从昼夜节律到极端时期。我们推测 老化暴露出的基本超极期是热 平衡时间为3小时。我们进一步假设渐进式 老化过程中的动态不稳定性导致联轴器的紧固 心血管压力电位变化和 超新陈代谢-热过程。孤立 收缩期高血压作为一种动态疾病出现，部分原因是 收紧或增加“动态刚性”。 临床意义：这项研究将提供必要的规范 在井队列中的老化过程中的收缩压。 此外，假设的(和已经观察到的)极端 SBP节律可作为心血管年龄的新标记物 在血压正常的受试者中。

LONG TERM OBJECTIVES: This Project seeks to define normative aging of the cardiovascular system by means of dynamic analysis of blood pressure and core temperature variations observed by 24 h ambulatory monitoring. Ultradian rhythms of systolic blood pressure (SBP) will be tested as markers of normative aging in well old subjects aged 60 years or older who are leading active lives in the community. Methods of linear and nonlinear spectroscopy will be used to extract circadian and ultradian rhythms. Our SPECIFIC AIM is to test the hypothesis that intrinsic aging leads to a shift in temporal organization away from circadian and toward ultradian periods. We conjecture that the fundamental ultradian period exposed by aging is the thermal equilibrium time of 3 h. We further hypothesize that progressive dynamic instability in aging leads to a tightening of the coupling between cardiovascular pressure potential variations and metabolic-thermal processes in the ultradian domain. Isolated systolic hypertension emerges as a dynamic disease based in part on that tightening or increasing "dynamic rigidity". CLINICAL IMPLICATIONS: This study will provide needed norms for systolic pressure over the course of aging in well cohorts. Furthermore, the postulated (and already observed) ultradian rhythms of SBP can serve as a new marker of cardiovascular age in normotensive subjects.