IMPAIRMENT OF MEMBRANE FUNCTION BY COMPLEMENT

通过免疫化学、脂质模型膜和生物物理的结合使用 膜探针光谱技术(EPR和荧光)， 黑色类脂膜和脂类单层技术，建议 研究补体介导过程中发生的分子事件 膜溶解。膜攻击复合体(MAC)的功能 将研究补体对膜的渗透性， 形成一个跨膜的蛋白质壁通道，重定向 有序的双层脂类，以及与其他膜蛋白的相互作用。这个 将特别研究MAC蛋白的病毒裂解作用。更饱满的人 对补体在人体免疫防御系统中作用的认识 将坚定不移地为新的更好的控制手段开辟道路 感染、过敏性疾病和自身免疫性疾病。

By combined use of immunochemistry, lipid model membranes, and biophysical techniques such as membrane probe spectroscopy (EPR and fluorescence), black-lipid membranes, and lipid monolayer techniques, it is proposed to investigate the molecular events that occur during complement mediated membranolysis. The function of the membrane attack complex (MAC) of complement will be investigated with respect to penetration into membranes, formation of a protein-walled channel across the membrane, reorientation of ordered bilayer lipids, and interaction with other membrane proteins. The virolytic action of MAC proteins will be studied in particular. A fuller understanding of the role of complement in the body's immune defense system will undoubetedly open the way to new and better means of controlling infections, allergic disorders, and autoimmune diseases.