SENSORY BASIS FOR BEHAVIOR IN MOSQUITOES

复杂的综合行为主要是过程的结果 在生物体的中枢神经系统中。 但 外周感觉系统起着决定性的作用， 这是CNS可以运行的基础。 而且 外周感觉器官可以决定哪种行为将被 表达。 一种似乎受到管制的行为，至少在 部分，通过女性外周受体系统的活动 蚊子的寄主寻找行为--一种与蚊子的寄主寻找行为直接相关的 疾病传播到人类和动物身上。 在 目前的研究，我们一直在调查体液 对宿主敏感的受体的诱导脱敏 引诱剂，乳酸（LA），和随后的抑制宿主- 嗜血之后的行为 我们确定了来源 的抑制因子作为脂肪体，并有初步的 有证据表明卵巢蜕皮激素 触发抑制剂的合成和/或释放。 在 此外，我们还提出了一个新的理论， 调制中的LA兴奋和LA抑制神经元， 控制主机寻求行为在拟议的研究。 我们 打算将这些调查扩展到下一阶段， 血餐后宿主寻找行为的抑制，特别是 抑制的维持和宿主的恢复- 产卵后寻找活动。 我们还打算研究 其他受体系统活性和潜在相互作用 寻找宿主的行为 本研究的最终目的是获得一个更好的 了解监管的机制， 控制雌蚊寻找寄主等行为。 这里开发的信息应该有助于确定如何 这些机制可能被用于减少 这些重要媒介传播疾病的可能性 有机体

Complex integrated behavior is primarily the result of processes in the central nervous system of an organism. However, the peripheral sensory system plays a decisive role in that it provides a basis on which the CNS can operate. Furthermore, the peripheral sensory organs may determine which behavior will be expressed. One behavior that appears to be regulated, at least in part, by the activity of a peripheral receptor system in female mosquitoes is host-seeking behavior--a behavior directly related to the transmission of diseases to man and his animals. In the current research, we have been investigating the humorally induced desensitization of the receptors sensitive to the host attractant, lactic acid (LA), and the subsequent inhibition of host- seeking behavior following a blood meal. We identified the source of the inhibitory factor as the fat body and have preliminary evidence that the ovarian ecdysteroids are responsible for triggering the synthesis and/or release of the inhibitor. In addition, we have postulated a new theory for the interaction of the LA-excited and LA-inhibited neurons in the modulation and control of host-seeking behavior in the proposed research. We intend to extend these investigations to the next stage in the post-blood meal inhibition of host-seeking behavior, specifically the maintenance of the inhibition and the recovery of host- seeking activity following oviposition. We also intend to examine the activity and potential interaction of other receptor systems with host-seeking behavior. The ultimate goal in this research is to gain a better understanding of the mechanisms underlying the regulation and control of host-seeking and other behaviors of female mosquitoes. The information developed here should aid in determining how these mechanisms might be employed in a strategy to reduce the potential for disease transmission by these important vector organisms.