A new universal mechanism controlling body proportions in animals

该项目旨在确定最近发现的一种机制，即抑制级联，决定了各种动物群体，特别是脊椎动物和节肢动物的附属物和身体部分的基本比例。该项目的目标是揭示小鼠和昆虫的分子机制，并建立计算机模拟来展示如何通过抑制级联来操纵发育控制。该项目将通过建立牙齿和肢体的操纵和再生控制机制，为生物工程带来好处。

This project aims to establish that a recently-discovered mechanism, the inhibitory cascade, determines the basic proportions of appendages and body segments in a diverse range of animal groups, particularly vertebrates and arthropods. The goals of the project are to reveal the molecular mechanisms in mice and insects, and build computer simulations to show how to manipulate the control of development by the inhibitory cascade. The project should benefit bioengineering by establishing control mechanisms for the manipulation and regeneration of teeth and limbs.