ACQUIRED IMMUNODEFICIENCY DISEASE IN HAITIAN CHILDREN

出生在迈阿密的海地婴儿有获得性免疫缺陷的证据 疾病综合征（艾滋病）和发展多种严重感染相关 T细胞亚群、免疫复合物和IgG升高显著逆转 程度. 提出了一个案例研究，以确定这一自然历史， 疾病和发展预后参数，以及提供一个基础， 用于各种形式的干预措施（如药物或 隔离 按照目前的病例发现速度， 每年都报名。 病毒排泄的频率和持续时间以及宿主 将监测对疱疹病毒家族选定成员的反应 纵向评估艾滋病患者与对照组的差异， 它们对常见病毒的主要反应 有证据表明，一部小说 代理人导致艾滋病。 儿科患者可以提供最佳来源， 病原体的检测。 将对艾滋病患者的组织进行研究 寻找与人类相关的整合病毒DNA序列的证据 逆转录病毒和与转化基因相关的序列， 在组织中激活。 索引病例的家庭成员和比较 将对家庭进行随访，以检测免疫异常的证据。 免疫异常个体，如T细胞亚群逆转 然后将进行前瞻性随访，以确定临床疾病是否是 T细胞亚群逆转的不可避免的后果或亚临床 出现异常。 一项实地研究，以确定相关风险因素 随着免疫缺陷的发展， 和问卷调查。 索引病例和对照家庭的家庭成员 将进行前瞻性随访，以确定获得性 免疫缺陷的家庭单位。 作为获得关于以下方面的试验数据的手段： 免疫缺陷的传播，怀孕的艾滋病妇女，怀孕的配偶 患有艾滋病的海地成年男性和指数婴儿的孕妇以及所有 他们的新生儿将被研究免疫功能和病毒 排泄

Haitian infants born in Miami have evidence on an acquired immunodeficiency disease syndrome (AIDS) and develop multiple severe infections associated with marked reversal of T-cell subsets, immune complexes and elevated IgG levels. A case study is proposed to define the natural history of this disease and to develop prognostic parameters, as well as provide a basis for benefit-risk analysis of various forms of intervention such as drugs or isolation. At the present rate of case detection 10-20 new cases will be enlisted each year. The frequency and duration of virus excretion and host responses to selected members of the Herpesvirus family will be monitored longitudinally to assess how AIDS patients differ from comparison groups in their primary responses to common viruses. Evidence suggests that a novel agent causes AIDS. Pediatric patients may provide an optimal source for detection of etiologic agents. Tissues of AIDS patients will be studied for evidence of integrated viral DNA sequences related to human retroviruses and for sequences related to transforming genes that may be activated in tissues. Family members of index cases and comparison families will be followed to detect evidence of immunologic abnormalities. Individuals with immunologic abnormalities such as T-cell subset reversal will then be followed prospectively to determine if clinical disease is an inevitable consequence of T-cell subset reversal or if subclinical abnormalities occur. A field study to determine risk factors associated with the development of immunodeficiency will be done by home visitation and questionnaires. Family members of index cases and comparison families will be followed prospectively to determine the frequency of acquired immunodeficiency in family units. As means of obtaining pilot data on transmission of immunodeficiency, pregnant AIDS women, pregnant consorts of adult Haitian males with AIDS and pregnant mothers of index infants and all their newborn infants will be studied for immune function and for virus excretion.