IMMOBILIZATION AND MOTION AFFECTS ON INJURED TENDONS

肌腱损伤在创伤病例中所占比例越来越大 在我们医院有报道，但对肌腱的分子生物学研究 医治一直被忽视。损伤后细胞的主要反应 肌腱是产生新的胶原蛋白和非胶原蛋白。胶原蛋白是 持续存在的关键结构蛋白，使肌腱有能力 抵抗拉力。胶原蛋白的交联量和位置很大 确定拉力阻力的大小。这是众所周知的 固定受伤的肢体会导致关节僵硬和 韧带和肌腱的顽固性粘连，影响活动能力。一个 亚稳的、可还原的胶原交联物的增加伴随着 机动性。受伤的肌腱应尽早进行轻度运动。 外科修复有利于愈合，因为某些亚稳态， 可还原的、稳定的吡啶酚交联物不能形成极限 动议。肌腱细胞如何对胶原反应和调节 受伤，以及制动或运动如何改变这些反应？这个 这项研究的总体目标是确定结构的变化 正在愈合的肌腱中的胶原蛋白 固定或运动。根据动物实验的结果，我们 希望将一种策略应用于涉及物理和化学的人类医学 促进肌腱愈合的干预措施。

Tendon injuries constitute an increasing proportion of trauma cases reported at our hospital, yet research in the molecular biology of tendon healing has been neglected. The major responses of cells in an injured tendon is to produce new collagen and noncollagen proteins. Collagen is the key structural protein that persists, giving tendon its ability to resist tensile forces. The collagen crosslink content and location largely determine the magnitude of the resistance to tensile force. It is known that immobilization of an injured limb leads to joint stiffness and intractable adhesions in ligaments and tendons that impair mobility. An increase in metastable, reducible collagen crosslinks accompanies loss of mobility. Mild exercise of an injured tendon as early as possible after surgical repair is favorable to healing because certain metastable, reducible, and stable pyridinoline crosslinks may not form to limit motion. How do tendon cells react to and regulate the collagen response to wounding, and how does immobilization or motion alter these responses? The overall objectives of this study are to identify changes in the structure of collagen in tendons that are healing and have been subjected to immobilization or motion. Based on results of animal experimentation, we hope to apply a strategy to human medicine involving physical and chemical intervention to improve tendon healing.