PHAGOCYTE CYTOSKELETON-COMPLEMENT RECEPTOR INTERACTIONS

白细胞补体（C）系统由八种类型的膜C组成 受体、白细胞合成的各种C组分和血浆C 与白细胞相互作用的成分。 本项目的目标是 来表征白细胞C系统的功能。 具体目标 （1）检测淋巴细胞的体外免疫应答 并确定白细胞C系统是否在识别 旁路途径（AP）激活剂通过因子B裂解， 膜C5或因子H（H）与膜H受体（H-R）的结合， 表征CR对淋巴细胞活化的抑制2 （C3 d-受体）配体，并确定这是否代表一种机制， AP的非激活剂的歧视;（2）检查的作用， 白细胞C系统在巨噬细胞和自然 （3）确定是否血清或效应细胞来源的C3是 沉积在AP激活的肿瘤细胞上，以及这是否代表 效应细胞与肿瘤细胞结合重要机制 受体;（4）检查白细胞C系统在中性粒细胞中的作用 对酵母聚糖和细菌的呼吸爆发响应;以及（5）确定 无论是iC 3b还是特定的碳水化合物， 微生物细胞壁触发呼吸爆发， 溶酶体酶通过C受体3型（CR）识别3). （简体中文）

The leukocyte complement (C) system consists of eight types of membrane C receptors, various C components synthesized by leukocytes, and plasma C components that interact with leukocytes. The objective of this project is to characterize the function of the leukocyte C system. The specific aims are as follows: (1) examine the in vitro immune response of lymphocytes and determine if the leukocyte C system has a role in recognition of alternative pathway (AP) activators through either factor B cleavage of membrane C5 or the binding of factor H (H) to membrane H receptors (H-R), characterize the suppression of lymphocyte activation by CR2 (C3d-receptor) ligands and determine if this represents a mechanism for discrimination of nonactivators of the AP; (2) examine the role of the leukocyte C system in the tumoricidal activity of macrophages and natural killer cells; (3) determine whether serum-\or effector cell-derived C3 is deposited onto AP-activating tumor cells and whether this represents an important mechanism for effector cell binding to tumor cells by way of C receptors; (4) examine the role of the leukocyte C system in the neutrophil respiratory burst response to zymosan and bacteria; and (5) determine whether either iC3b or specific carbohydrates contained in the microorganism cell walls trigger a respiratory burst and release of lysosomal enzymes through recognition by C receptor type three (CR3). (CS)