Agronomic processes to optimise galanthamine content of daffodil biomass (AGROGAL)

该项目旨在建立在阿尔茨海姆与伊格尔合作进行的前一项为期一年的研究的基础上，在选定的环境制度和不同的收获日期下考虑种植水仙的可行性(Morris等人05)。当时，经济回报预计仅为温和，因为含有加兰他明的药物受专利保护，而原料药水平相当低，加之提取和运输成本较高。含有原料药的配方现在是通用的，这项建议中详细说明的研究将建立在对不同水仙组织的连续收获的基础上，这些组织含有明显更高的加兰他明水平，已经在阿尔茨海姆进行了试验。将在该项目中处理的结果和研究将寻求通过应用最新的生物精炼原理，再加上全新的收获和提取制度，进一步降低成本，然后将这些制度与农学的发展、植物遗传资源的选择以及通过减少原料运输而节省的费用联系起来。通过供应支持旅游业的产品(香水、纸张、蜡)，生物精炼厂“副业”的销售应该会给当地经济带来附带利益。虽然这项研究的重点是最大限度地提高水仙花的生物碱含量，但也将提供信息，供花卉种植者直接利用，并间接供寻求将植物用作次生代谢物来源的其他生产商利用。具体地说，这项研究将展示种植者对气候变化所需的反应。研究产生的创新定性模型应涵盖所有预先存在的知识，并对各种试验的结果进行连贯的检验。此外，它们应该为类似系统的模型提供基础。定性模型应该使潜在的种植者能够确定他们的投资的预期回报。

This project aims to build on a previous one-year study undertaken by Alzeim in collaboration with IGER, where the feasibility of Narcissus cultivation was considered under selected environmental regimes and at different harvest dates (Morris et al 05). At that time, the economic returns were forecast to be only moderate, since pharmaceuticals containing galanthamine were protected by patents and API levels were quite low allied to high extraction and transport costs. Formulations containing the API are now generic and the research detailed in this proposal will build on sequential harvesting of different Narcissus tissues, containing significantly higher galanthamine levels, already piloted at Alzeim. The findings and research that will be addressed within this project will seek to further drive down costs by applying the latest biorefinery principles, coupled to entirely novel harvest and extraction regimes, which are then allied to developments in agronomy, choice of plant genetic resources and savings through reduced transport of feedstocks. Sales of the biorefinery 'side-streams' should result in spin-off benefits to the local economy through supply of products to support the tourism industry (perfume, paper, wax). Although focused on the objective of maximising the alkaloid content of daffodils, the research will also provide information that can be directly utilised by flower growers and indirectly by other producers seeking to use plants as sources of secondary metabolites. Specifically, the research will demonstrate the response required from growers to climate change. The innovative qualitative models produced by the research should capture all pre-existing knowledge and provide coherent tests of the results of the various trials. In addition, they should provide the foundation for models for analogous systems. The qualitative models should enable prospective growers to determine the expected returns on their investments.