CONTROL OF METRICAL & TIMING PRECISION IN HUMAN MOVEMENT

这项补助金的长期目标是确定 神经系统控制肢体的目标定向运动。 在 目标导向的运动，和重要的任务的紧张 系统将在电机命令中指定目标位置。 目标位置可以根据 控制惯性力所需的关节扭矩， 肢体运动的其他机械后果。 可选择地， 目标位置最初可以通过近似来指定， 根据过去类似运动任务的经验， 由纠错机制指定。 在上一个赠款周期，我们研究了生产的扭矩在 一个单一的等长关节，一个运动任务， 机械后果 在快速准确的变化中， 扭矩，目标扭矩由顺序控制 招募三个不同的控制机制， 近似和两个纠错机制。 之一 拟议研究的目的是进一步描述这些控制 机制等 另一个目的是评估一个运动任务， 生物力学更复杂，精确的运动， 关节 我们将确定是否同样的三个机制， 先前在扭矩响应中确定，也是控制肢体 动作 一旦我们了解了正常的神经系统是如何控制 运动和扭矩生产，我们将能够更好地 了解运动系统障碍的基础。 理解 正常的神经系统是如何解决肢体问题的 控制也可以使我们将这些解决方案应用于类似的 运动康复中的问题，例如，假肢控制和 麻痹肌肉的功能性刺激。 最后通过 我们对年轻成年人的研究可以与 其他年龄组，以更好地了解运动过程 系统开发和老化。

The long-term objective of this grant is to determine how the nervous system controls goal-directed movements of the limbs. In goal-directed movements, and important task of the nervous system is to specify target location in the motor command. Target location might be accurately specified in terms of the joint torques that are needed to control for inertial forces and other mechanical consequences of limb movement. Alternatively, target location might be initially specified by approximation, based on past experience with similar motor tasks, and later specified by error correction mechanisms. In the previous grant cycle, we studied the production of torque at a single isometric joint, a motor task having minimally complex mechanical consequences. During rapid and accurate changes in torque, target torque was controlled by the sequential recruitment of three distinct control mechanisms, an initial approximation and two error correction mechanisms. One of the aims of the proposed study is to further describe these control mechanisms. Another aim is to evaluate a motor task that is biomechanically more complex, accurate movement of a single joint. We will determine if the same three mechanisms that were previously identified in torque responses, also control limb movements. Once we understand how the normal nervous system controls movement and torque production, we will be better able to understand the basis of motor system disorders. Understanding how the normal nervous system has solved the problems of limb control may also allow us to apply these solutions to similar problems in motor rehabilitation, e.g., prosthesis control and functional stimulation of paralyzed muscle. Finally, the results of our studies of young adult subjects may be compared to studies of other age groups to better understand the processes of motor system development and aging.