TRABECULAR ARCHITECTURAL EFFECTS ON MATERIAL PROPERTIES

这个项目的目标是调查两者之间的关系 骨小梁的形态和构筑形态及其临床意义 机械性能。在第一阶段的调查中，我们有 发展了量化三维形态的能力， 骨小梁样本的连通性和各向异性 微型计算机断层扫描仪。此外，我们已经在实验中 推导出正交模与骨小梁之间的经验关系式 形态学。 这项建议的具体目标是： 1.验证和评价一种新的三维形态的使用 和结构算法，我们将其命名为“配置” 方法“。 2.通过实验开发出更具一般性的结构函数 人骨小梁的关系及其对青年和青年的预测价值 来自形态和建筑措施的剪切模数。 3.实验测定骨小梁组织模数的变化。 年龄和解剖位置的函数。 4.利用微观结构方法进行分析和实验 研究骨小梁结构的最佳性，并进行 形态和建筑因素的敏感性分析 有助于提高机械完整性。 该项目将包括测量骨小梁的形态和 使用微计算机断层扫描的架构，连续层级 材料测试和微结构材料测试。类比 程序将包括基于有限元的优化算法 与同质化理论相一致。 这些研究结果将为骨小梁的形成提供证据。 与结构优化相关的重塑策略。此信息 将支持继续努力了解双方之间的关系 生理、机械或环境改变和骨小梁。

The objective of this project is to investigate the relationship between the morphologic and architectural configuration of trabecular bone and its mechanical properties. During the first phase of investigation, we have developed the capabilities of quantifying three-dimensional morphology, connectivity, and anisotropy of trabecular bone samples utilizing a unique microcomputed tomography scanner. In addition, we have experimentally derived an empirical relationship between orthogonal moduli and trabecular morphology. The specific aims of this proposal are: 1. To validate and evaluate the use of a new three-dimensional morphologic and structural algorithm which we have designated the "configuration method". 2. To experimentally develop a more generalized structure function relationship for human trabecular bone in order to predict the Young's and shear moduli from morphologic and architectural measures. 3. To experimentally determine the variation in trabecular tissue moduli as a function of age and anatomic location. 4. Utilize a microstructural approach to analytically and experimentally investigate the optimality of trabecular structure and perform a sensitivity analysis on the morphologic and architectural factors that contribute to mechanical integrity. The project will involve measuring the trabecular bone morphology and architecture utilizing microcomputed tomography scanning, continuum level materials testing, and microstructural materials testing. The analtyical procedures will include finite element based optimization algorithms along with of homogenization theory. The results of these studies will provide evidence for trabecular bone remodeling strategies related to structural optimization. This information will support continuing efforts towards understanding relationships between physiologic, mechanical, or environmental alterations and trabecular bone.