NUCLEAR DIAGNOSTIC METHODS FOR RENAL DISEASE

为了提高活体成像技术对肾脏疾病的诊断水平， 将合成新的放射性物质以实现高肾脏 提取效率和肝脏提取效率低，这可以标记 用~(99m)Tc。这些化合物将包含双功能螯合物，如 亚氨基二乙酸、乙二胺二乙酸和氮三乙酸或 含硫配体。标记的低分子量蛋白质将 也可作为肾脏放射性药物进行开发。肾功能异常 ~(99m)Tc-二膦酸盐的累积将作为一种手段进行评估 药物性肾病患者肾脏钙代谢异常的检测 缺血性肾小管变性，以及结石形成的动物。至 肾放射性同位素研究的计数率数据的量化 闪烁相机-计算机技术，平均肾脏造影剂通过时间 将在反褶积分析后进行测量。结果将是 与肾血流量和肾组织学改变的测量结果进行比较 狗有三种不同类型的单侧肾缺血。连载 注射造影剂后肾脏的CT扫描 将其与核方法进行比较，以检测单侧 缺血症。

To improve the diagnosis of renal diseases by in vivo imaging techniques, new radioactive agents will be synthesized to achieve a high renal extraction efficiency and a low hepatic extraction, which can be labeled with Tc-99m. These compounds will contain bifunctional chelates such as iminodiacetic acid, ethylenediaminediacetic and nitrilotriacetic acid or sulphur-containing ligands. Labeled low molecular weight proteins will also be explored as renal radiopharmaceuticals. Abnormal renal accumulation of Tc-99m diphosphonates will be evaluated as a means of detecting abnormalities of renal calcium metabolism in drug-induced or ischemic renal tubular degeneration, and in stone-forming animals. To quantify counting rate data of renal radioisotope studies using scintillation camera-computer techniques, mean renal contrast transit times will be measured after deconvolution analysis. The results will be compared with measurements of renal blood flow and histological changes in dogs with three different types of unilateral renal ischemia. Serial transmission CT imaging of the kidneys following contrast medium injection will be compared with the nuclear methods for the detection of unilateral ischemia.