METAL RELEASE BY TOTAL REPLACEMENT PROSTHESES

临床研究显示金属关节面显著释放 离子种类从全关节置换，急性和 长远来看 体外细胞毒性和动物植入 研究表明，这种释放的有害生物作用 材料. 然而，它们的起源尚不清楚：它们可能是 由均匀腐蚀产生，或由磨损和磨损过程中产生 或者通过这些和其他过程的某种组合。 提出了一系列体外和体内研究来检查 两种常见合金体系中金属释放的某些特征 目前使用有：钴基和钛基。 四个主要 使用实验模型：体外被动释放， 从体内大鼠的阳极释放和循环加载和释放 推力 独立的实验材料参数将包括 合金成分、热处理和表面处理。 分析技术将包括原子吸收光谱法 (AAS)，扫描电子显微镜与电子衍射x- 射线分析（SEM/EDAX）和二次离子质谱 （西姆斯）。

Clinical studies have shown significant release of metal bearing ionic species from total joint replacements, both acutely and in the long term. In vitro cytotoxicity and animal implantation studies suggest adverse biological roles for such released materials. However, their origin is unclear: they may be produced by uniform corrosion, or by wear and fretting during articulation or by some combination of these and other processes. A series of in vitro and in vivo studies is proposed to examine some features of metal release in the two common alloy systems in use today: cobalt-base and titanium-base. Four main experimental models are to be used: in vitro passive release, anodic release and cyclic loading and release from an in vivo rat THR. Independent experimental material parameters will include alloy composition, heat treatment and surface treatment. Analytical techniques will include atomic absorption spectroscopy (AAS), scanning electron microscopy with electron diffraction x- ray analysis (SEM/EDAX) and secondary ion mass spectroscopy (SIMS).