课题基金 / 基金详情

CYTOMEGALOVIRUSES AND HUMAN MALIGNANCY

CYTOMEGALOVIRUSES AND HUMAN MALIGNANCY
巨细胞病毒与人类恶性肿瘤
批准号：
3165632
负责人：
Eng-Shang Huang
金额：
$10.77万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
项目状态：
已结题
起止时间：
1979-06-01 至 1987-06-30
来源：
https://reporter.nih.gov/project-details/3165632
关键词：
Betaherpesvirinae HeLa cells Hodgkin's disease Kaposi's sarcoma WI38 cell embryo /fetus tissue /cell culture endonuclease gel electrophoresis genetic manipulation genetic strain genome human tissue immunochemistry oncogenic virus radiotracer reproductive system neoplasm salivary gland neoplasms tissue /cell culture viral carcinogenesis virus DNA virus cytopathogenic effect virus genetics

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中文摘要
翻译
总体目标：本项目的总体目标是调查 人巨细胞病毒与不同人群的因果关系 恶性肿瘤，尤指病毒和细胞之间的相互作用 疱疹病毒的致癌机制。 为本年度确定的目标：1.继续努力检测 人巨细胞病毒DNA基因组在多种肿瘤组织中的存在。2.确立 各种CMV DNA片段的重组DNA文库。3.继续 努力寻找与病毒致癌有关的巨细胞病毒DNA。4. 比较我国黄瓜花叶病毒分离株的生物学特性 肿瘤和各种临床表现。
英文摘要
OVERALL OBJECTIVES: The overall objective of this project is to investigate the causal association between human cytomegalovirus (human CMV) and various human malignancies, especially the virus and cell interactions that might bear upon the mechanism of herpes virus oncogenesis. GOALS SET FOR CURRENT YEAR: 1. To continue the effort in the detection of the existence of human CMV DNA genome in various cancer tissues. 2. To establish the recombinant DNA library for various CMV DNA fragments. 3. To continue the effort in searching for CMV DNA which is responsible for viral oncogenesis. 4. To compare the biological characteristics of various CMV strains isolated from tumor and various clinical manifestations.
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HCMV DYSREGULATES ENDOTHELIAL CELL FUNCTIONS
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
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