KIDNEY RESPONSE TO FRACTIONATED RADIATION

这个项目的目标是研究肾脏对 分次辐射以及这种辐射与普通辐射的相互作用 化疗剂。 对非增殖组织的晚期损伤是一种 放射治疗和使用联合放射治疗的主要限制因素， 化疗正在增加。 最近的信息很少 分次放射治疗的组织损伤和 在这些组织中的药物-辐射相互作用。 具体目标是：（1） 研究辐射耐受性的时间依赖性或缺乏时间依赖性 2）研究治疗中长时间和短时间间隔的影响 对肾脏辐射耐受性的影响; 3）确定年龄 肾的辐射耐受性的依赖性; 4）确定 保护程度由部分肾屏蔽产生， 5）研究慢性给药对大鼠肝细胞的影响 化疗药物对放射性肾毒性的影响; 6）确定 肾脏照射对甲氨蝶呤药代动力学的影响。 这些实验将在大鼠中模拟药物辐射剂量， 因此，辐射和药物将成为 以分次剂量给予未麻醉的动物。

The goal of this project is to study the response of the kidney to fractionated radiation and the interaction of this irradiation with common chemotherapeutic agents. Late damage to nonproliferating tissues is a major limiting factor in radiotherapy and the use of combined radiation and chemotherapy is increasing. There is a paucity of information on late tissue damage from fractionated radiotherapy and on the effects of drug-radiation interactions in such tissues. Special Aims are: 1) To study the time-dependence, or the lack thereof, of the radiation tolerance of the kidney; 2) to study the effects of long and short gaps in treatment on the radiation tolerance of the kidney; 3) to determine the age dependence of the radiation tolerance of the kidney; 4) to determine the extent of protection produced by partial kidney shielding during irradiation; 5) to study the effects of chronic administration of common chemotherapeutic agents on the renal toxicity of radiation; 6) to determine the effects of kidney irradiation on the pharmacokinetics of methotrexate. These experiments will simulate in rats the drug-radiation doses and schedules used in man. Radiation and drugs will, therefore, be administered in fractionated doses to unanesthetized animals.