ENHANCING SMOKING CESSATION BY WEIGHT GAIN PREVENTION

肺癌的死亡率现已超过乳腺癌，成为最大的死亡率。 导致女性癌症死亡的原因，反映出 近几十年来的女性。调查和实验数据表明，女性 戒烟的难度比男性更大。各种各样的社交， 对这个问题的心理和行为解释一直是 暗示了男性和女性之间最普遍的差异之一 吸烟者是女性对戒烟后体重增加的更大恐惧。这个 戒烟后体重增加的机制尚不完全清楚。 但对这一问题的了解足以提出限制 这种常见的戒烟后遗症的影响。 一项涉及360名女性吸烟者的随机临床试验(RCT) 对戒烟后体重增加的担忧将测试行为和 药理上的体重增加预防策略。重量控制 关注体重维持和通过口香糖替代尼古丁的策略 将从行为和生理两个方面阐述这一共同的 有问题。这两种治疗方法都将侧重于减少对体重大幅增加的恐惧 以及接受戒烟后微小但常见的体重增加。全 随机的受试者将接受美国肺脏协会(ALA)的治疗 戒烟自由(FFS)诊所计划(七次戒烟 计划)。在2X2随机对照试验设计中，受试者将随机接受(A) 体重的多组分行为自学治疗(BSST) 预防获取或关于这一主题的小型ALA小册子，以及(B) 尼古丁(含尼古丁)口香糖或不含口香糖。据预测， BSST和Nicorette口香糖条件均经过化学验证 禁酒率在12个月的随访率从50%到 在仅ALA FFS组中，合并情况降至15%。设计 将有足够的能力来检测预测的主要和交互效果 使用戒烟率的对数线性分析，多重Logit生存分析 复发率的统计分析和连续依赖的协方差分析 变量。 这项研究旨在提高泛化能力。如果尼科雷特口香糖 或BSST提高全国可用ALA的持续戒烟率 FFS临床计划用于关注女性吸烟者 戒烟后体重增加，能够有效地吸引女性 戒烟选择将显著增强。

Death rates for lung cancer have now surpassed breast cancer as the leading cause of cancer deaths in women, reflecting the increase in smoking among women in recent decades. Survey and experimental data suggest that women have greater difficulty quitting cigarettes than men. Various social, psychological, and behavioral explanations of this problem have been suggested but one of the most prevalent differences between male and female smokers is the greater fear of post-cessation weight gain among women. The mechanisms accounting for post-cessation weight gain are not fully known but knowledge of the problem is sufficient to propose strategies to limit the impact of this common sequelae of cessation. A Randomized Clinical Trial (RCT) involving 360 female smokers with an expressed concern about post-cessation weight gain will test behavioral and pharmacological weight gain prevention strategies. Weight control strategies focused on weight maintenance and nicotine replacement via gum will address both behavioral and physiological aspects of this common problem. Both treatments will focus on reducing fear of large weight gains and acceptance of small but common post-cessation weight gains. All randomized subjects will receive the American Lung Association (ALA) Freedom From Smoking (FFS) Clinic Program (seven-session smoking cessation program). In a 2X2 RCT design, subjects will be randomized to receive (a) either a multi-component Behavioral Self-Study Treatment (BSST) for weight gain prevention or a small ALA pamphlet on the topic, and (b) either Nicorette (nicotine containing) gum or no gum. It is predicted that the BSST and Nicorette gum conditions with both enhance chemically validated abstinence rates at the 12-month follow-up with rates varying from 50% in the combined condition down to 15% in the ALA FFS only group. The design will have sufficient power to detect predicted main and interactive effects using log-linear analyses of quit rates, multiple-logit survival analyses of relapse rates, and analysis of covariance of continuous dependent variables. The study is designed to enhance generalizability. If either Nicorette gum or the BSST enhance the sustained quit rate of the nationally available ALA FFS Clinic program when used with female smokers concerned about post-cessation weight gain, the ability to attract females to an effective smoking cessation option will be significantly enhanced.