Ultrasensitive electrochemical biosensors

该项目旨在开发能够将生化信号转化为电子信号的新型蛋白质。利用蛋白质工程，该项目将生产基于氧化还原蛋白质的关闭开关。该项目预计，OFF开关（与ON开关相反）的使用将简化生物传感器设计，并创建一类新的传感器架构。基于OFF开关的生物传感器与酶信号放大电路的集成有望产生具有近实时响应的超灵敏传感系统。该项目将满足对新技术的需求，这些技术能够在专业实验室之外以低成本快速收集生理和环境信息。

This project aims to develop novel proteins that can convert biochemical cues into electronic signals. Using protein engineering, this project will produce redox protein-based OFF switches. The project expects that the use of the OFF-switches (as opposed to ON switches) will simplify biosensor design and create a new class of sensory architectures. Integration of OFF-switch-based biosensors with an enzymatic signal amplification circuit is expected to yield ultrasensitive sensory systems with near-real-time response. The project will address a need for new technologies that enable collection of physiological and environmental information rapidly, and at low cost outside of the specialised laboratories.