CHARACTERIZATION OF INDUCED NEUROENDOCRINE LUNG CANCER

神经内分泌肺癌是最常见的肺癌类型之一。 吸烟者的癌症，但从未在动物身上诱发过。 这 该项目是基于发现，同时暴露的 仓鼠高氧和二乙基亚硝胺（DEN）诱导的 高氧时神经内分泌肺癌发病率高 单独或单独DEN导致肺动脉压显著增加， 内分泌细胞 这种独特的体内模型具有潜在的巨大潜力。 重要的是研究发展机制， 对恶性肿瘤以及化学预防和 治疗研究。 然而，所有这些的先决条件 研究是对肿瘤的深入表征。 的 该项目的具体目标是：研究病理学， 神经内分泌学与神经内分泌肺的分子生物学 在叙利亚金黄地鼠中通过暴露于 高氧和DEN，并将病理变化与 肿瘤发生过程中神经内分泌和遗传标记物的变化 发展

Neuroendocrine lung cancer is one of the most common types of cancer in smokers but has never been induced in an animal. This project is based on the discovery that simultaneous exposure of hamsters to hyperoxia and diethylnitrosamine (DEN) induces a high incidence of neuroendocrine lung cancers while hyperoxia alone, or DEN alone lead to a pronounced increase of pulmonary endocrine cells. This unique in vivo model is of potentially great importance for studies into mechanisms of development of this poorly understood malignancy as well as chemopreventive and therapeutic investigations. However, a prerequisite for all such research is an in-depth characterization of the tumors. The specific aims of this project are: To study the pathology, neuroendocrinology and molecular biology of neuroendocrine lung tumors induced in Syrian golden hamsters by exposure to hyperoxia and DEN and to correlate pathological changes with alterations in neuroendocrine and genetic markers during tumor development.