14-ATC2. Engineering resistance to disease in pigs

该项目通过减少疾病造成的浪费来提高生产效率，从而减少猪肉生产的碳足迹，从而解决粮食安全和环境可持续性问题。我们将针对流感病毒对我国核心畜牧业之一的重大影响。猪流感（SIV）一直是影响种畜、苗圃和育肥畜的三大经济疾病之一。此外，流感是猪的头号人畜共患病毒性疾病。我们的策略是基于最近在鸡身上验证的一种新的RNA诱饵方法。我们现在的目标是利用这项新开发的技术生产基因工程（GE）猪，表达新的RNA分子，旨在防止SIV的复制和繁殖。我们的目标是减轻甚至消除猪SIV感染造成的死亡率和发病率，同时通过减少人畜共患流感大流行的可能性来额外保护人类健康。这个项目的目的是作为一个“原型”研究，如果成功，通过进一步的方法改进导致商业产品的开发。

This project addresses food security and environmental sustainability by increasing production efficiency by reducing wastage due to disease and thus decreasing the carbon footprint of pork production. We will target the significant impact of influenza virus on one of our core livestock industries. Swine influenza (SIV) ranks consistently among the top 3 economic diseases affecting breeding, nursery, and finishing herds. In addition, influenza is the top zoonotic viral disease of swine. Our strategy is based on the recent validation of a novel RNA decoy approach in chickens. We now aim to use this newly developed technology to produce genetically engineered (GE) pigs expressing novel RNA molecules designed to prevent replication and propagation of SIV. We aim to mitigate or even eliminate mortality and morbidity due to SIV infection in pigs, while additionally protecting human health by reducing the zoonotic flu pandemic potential. It is the intention that this project will function as a 'prototype' study and, if successful, with further method refinement lead to development of a commercial product.