Ambulatory microdialysis sampling system

布里斯托尔大学的斯塔福德·莱特曼教授开发了一种医疗设备，可以在一天24小时，包括在不受干扰的睡眠期间，对受试者进行微创自动定期样本采集。这将首次实现对临床和生物分析物的详细研究，已知这些分析物在一天中会发生变化。该设备在基础研究、动物和人类疾病的预测和诊断、临床试验和药物开发以及治疗监测方面具有潜在的应用。该项目将通过开发该设备的试生产原型来提供商业原理证明，该设备更加用户友好，足够灵活，可以在一系列研究场景中使用，并且足够坚固，可以在大型动物和人类身上使用。这将得到充分的测试和验证，并准备好在MAN和CE标记中进行试验。获得CE认证将为该设备作为研究工具出售铺平道路，无论是通过授权公司还是通过衍生公司。

Prof Stafford Lightman (Univ Bristol) has developed a medical device for the minimally invasive automated collection of regular samples from a subject 24 hours a day, including during undisturbed sleep. For the first time, this will enable the detailed study of clinical and biological analytes known to vary over the day. The device has potential applications in basic research, for prognosis and diagnosis of disease in animals and man, in clinical trials and drug development and for therapeutic monitoring. This project will deliver commercial proof of principle by developing a pre-production prototype of the device which is more user-friendly, flexible enough to be used in a range of research scenarios, and robust enough to be used on large animals as well as in man. This will be fully tested and validated, and ready for trials in man and CE marking. Achievement of a CE mark will pave the way for the device to be sold as a research tool, either through a licensee or a spinout company.