QUANTITATIVE EVALUATION OF CLINICAL HYPERTHERMIA

如果要进行热疗，量化热剂量的能力是必不可少的。 被用来治疗癌症。然而，目前还没有可以接受的方法 是存在的。这一问题的解决需要在两个领域取得重大进展： A)精确的组织三维测量(或计算) 温度(温度映射)和b)这些温度的转换 将测量结果纳入治疗描述，这是应答的预测因素。 虽然第一个领域超出了本项目的范围，但本项目的目标是 提案的目的是通过进一步推动 一种临床有用的计算热剂量的方法的发展 在热疗期间收集的时间和温度信息。 为此，提出了一种简单的热剂量计算方法。 并由首席调查员描述。一些临床报告， 在人体试验和宠物动物自发性肿瘤试验中 已经证明，这种方法是对反应的预测，而且可能是最好的 可利用的方法。这项建议旨在改善和改善 采用这种方法来解释一些已知的因素 影响热效应，还将尝试研究 量化热处理的替代方法。这些说明是 体现在以下四个具体目标上：1)第一个目标是 进一步发展热等效应剂量概念和计算，以 解释了a)降温、b)热适应的现象 以及c)耐热性。为此，将获得体外数据以 提供对这些数据进行数学描述所需的信息 现象。这些改进的体内测试将使用 小鼠正常骨髓和肿瘤。2)第二个目的是调查 热疗联合应用时的时间-温度关系 放射或化疗药物。3)第三个目标是调查 热剂量的空间分布在辐射反应中的重要性 临床治疗及空间描述方法的评价 在可预测的情况下使用小鼠肿瘤系统进行剂量分布 温度梯度是可以复制的。4)第四个目标是发展， 分发和维护热疗数据文件标准格式和 可用于评估剂量模型的计算机程序 具有实际临床数据的机构。

The ability to quantify thermal dosage is essential if hyperthermia is to be used for the treatment of cancer. However, no acceptable method yet exists. The solution to this problem demands major advances in two areas: a) the accurate three dimensional measurement (or calculation) of tissue temperatures (temperature mapping) and b) the conversion of these measurements into a treatment description which is a predictor of response. While the first area is beyond the scope of this project, the goal of this proposal is to address the second of these problems by furthering the development of a clinically useful means of calculating thermal dose from time and temperature information gathered during hyperthermia therapy. Towards this goal, a simple thermal dose calculating method was developed and described by the principal investigator. A number of clinical reports, both in human trials and in trials on spontaneous tumors in pet animals have shown that this method is predictive of response and may be the best approach available. This proposal is directed toward improving and adapting this approach to account for some of the factors which are known to influence thermal effects and will also attempt to investigate alternative means of quantifying thermal treatments. These directions are reflected in the following four specific aims: 1) The first aim is to further develop thermal iso-effect dose concepts and calculations to account for the phenomena of a) step-down heating, b) thermal adaptation and c) thermotolerance. To this end, in vitro data will be obtained to provide the information necessary for the mathematical description of these phenomena. In vivo testing of these improvements will be performed using murine normal bone marrow and tumors. 2) The second aim is to investigate the time-temperature relationship when hyperthermia is combined with radiation or chemotherapeutic agents. 3) The third aim is to investigate the importance of spatial distribution of thermal dose in the response to clinical treatment and to evaluate methods of describing the spatial distribution of dose by using a murine tumor system where predictable thermal gradients can be reproduced. 4) The fourth aim is to develop, distribute and maintain a Hyperthermia Data File Standard format and computer programs which can be used to evaluate dose models by any institution with actual clinical data.