EFFECT OF FOOD/TASTE PREFERENCES ON DRUG INTAKE

影响人体摄入量的先天因素和环境因素的交互作用 人们对酒精和其他药物知之甚少。以前的研究，包括 我们自己的初步调查表明：(1)食物匮乏 导致各种组织的自我管理发生重大变化 大鼠的药物(以及脂肪和甜味偏好的变化)；(2) 大鼠对高脂肪饮食和/或甜味的偏好与 自我给药；(3)大鼠表现出伟大的、与生俱来的 他们对高脂肪饮食和/或高脂肪饮食偏好的个体差异 甜美的口感。因此，我们假设，不同于 对高脂肪或甜味Instera的偏好在口腔方面会有所不同 酒精、乙硝氮烯和可卡因的注射。此外，我们 假设食物剥夺可能对药物有不同的影响 不同常量营养素和口感的大鼠自身给药 偏好。我们将采用单瓶进食模式进行初始 这些饮食偏好之间的关系的调查 变量和药物自我管理；更细粒度的分析 这些变量的交互作用将通过运算符执行 条件反射。如果假设的饮食和口味之间的关系 确认偏好和药物自我给药，然后进一步 味觉与饮食偏好关系的调查研究 表明在人类中使用药物。潜在地，味觉反应的衡量标准 或者饮食偏好可以用来筛查那些患高血压的高危人群 过度使用药物的发展。

The interaction of inborn and environmental determinants of the intake of alcohol and other drugs is poorly understood. Previous studies, including our own preliminary investigations, have shown that: (1) food deprivation causes significant changes in the self-administration of a variety of drugs (as well as changes in fat and sweet taste preference) in rats; (2) the preference of rats for high-fat diets and/or sweet taste is related to drug selfadministration; and (3) rats demonstrate great, innate inter-individual variability in their preference for high-fat diets and/or sweet taste. Therefore, we hypothesize that rats which differ in preference for high-fat or sweet ingesta will differ in oral self administration of alcohol, etonitazene, and cocaine. Furthermore, we hypothesize that food deprivation may have different effects on the drug self-administration of rats with different macronutrient or taste preferences. We will employ a single-bottle intake paradigm for initial investigations of the relationships between these diet preference variables and drug self-administration; more fine-grained analysis of the interactions of these variables will be performed with operant conditioning. If the hypothesized relationships between diet and taste preference and drug self-administration are confirmed, then further investigations into the relationship of taste and diet preferences and drug use in humans are indicated. Potentially, measures of taste response or diet preference could be used to screen for those at high risk for the development of excessive drug use.